Candida auris: An Overview of How to Screen, Detect, Test and Control This Emerging Pathogen.
Teresa Fasciana,Andrea Cortegiani,Mariachiara Ippolito,Antonino Giarratano,Orazia Di Quattro,Dario Lipari,Domenico Graceffa,Anna Giammanco +7 more
TLDR
A brief overview highlighting some of the critical aspects of sample collection, laboratory culture-dependent and independent identification and the susceptibility profile of C. auris is offered.Abstract:
The multidrug-resistant yeast Candida auris is associated with invasive infections in critically ill patients and has been isolated in different countries worldwide. Ease of spread, prolonged persistence in the environment and antifungal drug resistance pose a significant concern for the prevention of transmission and management of patients with C. auris infections. Early and correct identification of patients colonized with C. auris is critical in containing its spread. However, this may be complicated by C. auris strains being misidentified as other phylogenetically related pathogens. In this review, we offer a brief overview highlighting some of the critical aspects of sample collection, laboratory culture-dependent and independent identification and the susceptibility profile of C. auris.read more
Citations
More filters
Journal ArticleDOI
Diagnosis and Treatment of Invasive Candidiasis
TL;DR: Therapeutic options for invasive candidiasis are generally limited to four classes of systemic antifungals (polyenes, antimetabolite 5-fluorocytosine, azoles, echinocandins) with the two latter being highly effective and well-tolerated and hence the most widely used.
Understanding echinocandin resistance in the emerging pathogen .
Milena Kordalewska,Annie Lee,Steven I. Park,Indira Berrio,Anuradha Chowdhary,Yanan Zhao,David S. Perlin +6 more
Journal ArticleDOI
Candida auris: An Overview of the Emerging Drug-Resistant Fungal Infection
Adekunle Sanyaolu,Chuku Okorie,Aleksandra Marinkovic,Abu Fahad Abbasi,Stephanie Prakash,Jasmine Mangat,Zaheeda Hosein,Nafees Haider,J. Chan +8 more
TL;DR: Candida auris is rapidly spreading across healthcare settings globally and monitoring of its virulence as well as devising appropriate treatment approaches are thus highly required.
Journal ArticleDOI
Characteristics, Risk Factors, and Survival Analysis of Candida auris Cases: Results of One-Year National Surveillance Data from Oman.
Azza Al-Rashdi,Amal Al-Maani,Adil Al-Wahaibi,Abdullah Alqayoudhi,Amina Al-Jardani,Seif Al-Abri +5 more
TL;DR: In this paper, a retrospective analysis was conducted for all C. auris cases reported nationally to the Oman Antimicrobial Surveillance System (OMASS) in 2019, and isolates were sent to the Central Public Health Laboratories (CPHL).
Journal ArticleDOI
International Multicentre Study of Candida auris Infections.
Nirav Pandya,Yasemin Cag,Nenad Pandak,Abdullah Umut Pekok,Aruna Poojary,Folusakin Ayoade,Teresa Fasciana,Anna Giammanco,Hulya Caskurlu,Dhanji P. Rajani,Yogesh Kumar Gupta,Ilker Inanc Balkan,Ejaz Ahmed Khan,Hakan Erdem +13 more
TL;DR: In this paper, the authors conducted a retrospective observational multicentre study to determine the epidemiology of C. auris infections, its management strategies, patient outcomes, and infection prevention and control practices across 10 centres from five countries.
References
More filters
Journal ArticleDOI
Simultaneous Emergence of Multidrug-Resistant Candida auris on 3 Continents Confirmed by Whole-Genome Sequencing and Epidemiological Analyses
Shawn R. Lockhart,Kizee A. Etienne,Snigdha Vallabhaneni,Joveria Farooqi,Anuradha Chowdhary,Nelesh P. Govender,Arnaldo Lopes Colombo,Belinda Calvo,Christina A. Cuomo,Christopher A. Desjardins,Elizabeth L. Berkow,Mariana Castanheira,Rindidzani E. Magobo,Kauser Jabeen,Rana Jawad Asghar,Jacques F. Meis,Brendan R Jackson,Tom Chiller,Anastasia P. Litvintseva +18 more
TL;DR: Candida auris is an emerging healthcare-associated pathogen associated with high mortality, and WGS analysis suggests nearly simultaneous, and recent, independent emergence of different clonal populations on 3 continents.
Journal ArticleDOI
Candida auris sp. nov., a novel ascomycetous yeast isolated from the external ear canal of an inpatient in a Japanese hospital
TL;DR: A single strain of a novel ascomycetous yeast species belonging to the genus Candida was isolated from the external ear canal of an inpatient in a Japanese hospital and indicated that this strain represents a new species with a close phylogenetic relationship to Candida ruelliae and Candida haemulonii in the Metschnikowiaceae clade.
Journal ArticleDOI
First hospital outbreak of the globally emerging Candida auris in a European hospital
Silke Schelenz,Ferry Hagen,Johanna Rhodes,Alireza Abdolrasouli,Anuradha Chowdhary,Anne Hall,Lisa Ryan,Joanne Shackleton,Richard Trimlett,Jacques F. Meis,Darius Armstrong-James,Matthew C. Fisher +11 more
TL;DR: This ongoing outbreak with genotypically closely related C. auris highlights the importance of appropriate species identification and rapid detection of cases in order to contain hospital acquired transmission.
Journal ArticleDOI
Regulatory Circuitry Governing Fungal Development, Drug Resistance, and Disease
TL;DR: The circuitry regulating fungal morphogenesis and drug resistance and the impact of these pathways on virulence are reviewed, which represent a minute fraction of fungal diversity.
Journal ArticleDOI
Multidrug-Resistant Candida auris Misidentified as Candida haemulonii: Characterization by Matrix-Assisted Laser Desorption Ionization–Time of Flight Mass Spectrometry and DNA Sequencing and Its Antifungal Susceptibility Profile Variability by Vitek 2, CLSI Broth Microdilution, and Etest Method
Shallu Kathuria,Pradeep Kumar Singh,Cheshta Sharma,Anupam Prakash,Aradhana Masih,Anil Kumar,Jacques F. Meis,Anuradha Chowdhary +7 more
TL;DR: A cautionary approach is recommended for laboratories relying on commercial systems for identification and antifungal susceptibility testing of rare yeasts, as 90% of the isolates characterized by commercial identification systems are misidentified as C. auris.