Journal ArticleDOI
Cardiac excitation–contraction coupling
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TLDR
Of the ions involved in the intricate workings of the heart, calcium is considered perhaps the most important and spatial microdomains within the cell are important in localizing the molecular players that orchestrate cardiac function.Abstract:
Of the ions involved in the intricate workings of the heart, calcium is considered perhaps the most important. It is crucial to the very process that enables the chambers of the heart to contract and relax, a process called excitation-contraction coupling. It is important to understand in quantitative detail exactly how calcium is moved around the various organelles of the myocyte in order to bring about excitation-contraction coupling if we are to understand the basic physiology of heart function. Furthermore, spatial microdomains within the cell are important in localizing the molecular players that orchestrate cardiac function.read more
Citations
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Voltage-Gated Calcium Channels
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Kacey Ronaldson-Bouchard,Stephen P. Ma,Keith Yeager,Timothy Chen,LouJin Song,Dario Sirabella,Kumi Morikawa,Diogo Teles,Diogo Teles,Masayuki Yazawa,Gordana Vunjak-Novakovic +10 more
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References
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PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts.
Steven O. Marx,Steven Reiken,Yuji Hisamatsu,Thotalla Jayaraman,Daniel Burkhoff,Nora Rosemblit,Andrew R. Marks +6 more
TL;DR: It is shown that protein kinase A (PKA) phosphorylation of RyR2 dissociates FKBP12.6 and regulates the channel open probability (Po), resulting in defective channel function due to increased sensitivity to Ca2+-induced activation.
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Calcium sparks: elementary events underlying excitation-contraction coupling in heart muscle
TL;DR: The calcium spark is the consequence of elementary events underlying excitation-contraction coupling and provides an explanation for both spontaneous and triggered changes in the intracellular calcium concentration in the mammalian heart.
Journal ArticleDOI
Excitation-Contraction Coupling and Cardiac Contractile Force.
Donald M. Bers,Yujie Zhu +1 more
TL;DR: The major cellular structures involved in E-C coupling include myofilaments, Na/Ca exchange and the sarcolemmal Ca-pump as mentioned in this paper, as well as the sources and sinks of activator calcium.
Journal ArticleDOI
Calmodulin supports both inactivation and facilitation of L-type calcium channels
TL;DR: Calmodulin is shown to be a critical Ca2+ sensor for both inactivation and facilitation, and that the nature of the modulatory effect depends on residues within the IQ motif important for calmodulin binding.