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Cell-Penetrating Peptides as Passive Permeation Enhancers for Transdermal Drug Delivery
Lipika Chablani,Vijay Singh +1 more
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In this paper , the authors highlight the advances made in preclinical and clinical research using cell-penetrating peptides since their discovery in 1980s and summarize the role of cell peptides as permeation enhancers for transdermal and topical drug delivery applications.Abstract:
Cell-penetrating peptides have been widely used as a tool to gain access to cytosol for numerous applications. The review highlights the advances made in preclinical and clinical research using cell-penetrating peptides since their discovery in 1980s. Further, the emphasis is on summarizing the role of cell-penetrating peptides as permeation enhancers for transdermal and topical drug delivery applications. A summary table of preclinical studies utilizing various peptides in combination with different active ingredients and drug delivery systems is included. Lastly, we capture the challenges associated with the cell-penetrating peptides to translate the preclinical work to clinical applications.read more
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The mimicked cell penetration peptides of chitosan derivates with low molecular weight for transdermal enhancement studies
Jia-zhan Lv,Meihua Jiang,Yaru Fang,Wenchang Zhang,Minna Wu,Fanghao Zheng,Kaijun Lei,Leiwei Shang,Yan Zhao +8 more
TL;DR: In this article , the biomimetic chitosan derivatives synthesized by chemical coupling of L-arginine onto chitoshan with low molecular weight, named Arg-CS, which was prepared by mimicking the arginine-rich peptides, to achieve the permeability performance of Cell-penetrating peptides (CPPs).
References
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Journal ArticleDOI
Regulated portals of entry into the cell
Sean D. Conner,Sandra L. Schmid +1 more
TL;DR: ‘Endocytosis’ encompasses several diverse mechanisms by which cells internalize macromolecules and particles into transport vesicles derived from the plasma membrane and must be viewed in a broader context than simple vesicular trafficking.
Journal ArticleDOI
Transducible TAT-HA fusogenic peptide enhances escape of TAT-fusion proteins after lipid raft macropinocytosis.
TL;DR: It is shown that after an initial ionic cell-surface interaction, TAT-fusion proteins are rapidly internalized by lipid raft–dependent macropinocytosis, and a transducible, pH-sensitive, fusogenic dTAT-HA2 peptide is developed that markedly enhanced Tat-Cre escape from macropinosomes.
Journal ArticleDOI
Dermal and transdermal drug delivery systems: Current and future prospects
TL;DR: For these novel delivery methods to succeed and compete with those already on the market, the prime issues that require consideration include device design and safety, efficacy, ease of handling, and cost-effectiveness.
Journal ArticleDOI
Insight into the mechanism of the peptide-based gene delivery system MPG: implications for delivery of siRNA into mammalian cells
TL;DR: The mechanism through which MPG promotes gene delivery is investigated, it is demonstrated that cell entry is independent of the endosomal pathway and that the NLS of MPG is involved in both electrostatic interactions with DNA and nuclear targeting, and specific variations in the sequence may yield carriers with distinct targeting features.
Journal ArticleDOI
Improving the endosomal escape of cell-penetrating peptides and their cargos: strategies and challenges.
TL;DR: This review surveys how CPPs labeled with chromophores can be used in combination with light to stimulate endosomal lysis and discusses the recent development of branched systems that display multiple copies of a CPP.
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