Open AccessJournal Article
Cerebrospinal fluid homovanillic acid in male alcoholics: effects of disulfiram.
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TLDR
The possibility that some of disulfiram's effects are related to alterations in biogenic amine metabolism led to the present study of cerebrospinal fluid amine metabolites in a group of male alcoholics, which indicated a significant reduction in homovanillic acid and no change in 5-hydroxyindoleacetic acid.About:
This article is published in Biological Psychiatry.The article was published on 1977-01-09 and is currently open access. It has received 36 citations till now. The article focuses on the topics: Disulfiram & Homovanillic acid.read more
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Pharmacotherapy of addictions
TL;DR: The current approved and implemented pharmacotherapeutic approaches to the treatment of addiction are summarized, and the most promising areas for future drug development are highlighted from the perspective of the laboratory and NIDA Research Center.
Journal ArticleDOI
Alcohol and Central Serotonin Metabolism in Man
TL;DR: The CSF metabolites of serotonin and dopamine, 5-hydroxyindoleacetic acid, and homovanillic acid were studied in hospitalized alcoholics, and there were no significant differences in HVA levels between groups.
Journal ArticleDOI
DRD2 dopamine receptor genotype, linkage disequilibrium, and alcoholism in American Indians and other populations
David Goldman,Gerald L. Brown,Bernard Albaugh,Rob Robin,Susan Goodson,Marie Trunzo,Longina A. Akhtar,Susan Lucas-Derse,Jeffrey C. Long,Markku Linnoila,Michael Dean +10 more
TL;DR: The existence of large interpopulation differences in the frequency of the Taq1 alleles suggests that associations to disease status could readily be generated or masked if disease and control groups were uneven in ethnic composition.
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D2 dopamine receptor genotype and cerebrospinal fluid homovanillic acid, 5-hydroxyindoleacetic acid and 3-methoxy-4-hydroxyphenylglycol in alcoholics in Finland and the United States.
David Goldman,Michael Dean,Gerald L. Brown,A. M. Bolos,Riitta A Tokola,Matti Virkkunen,Markku Linnoila +6 more
TL;DR: There was no relationship between D2/Taq 1 genotype and concentrations of these monoamine metabolites in this group, which exhibits lower CSF HVA and 5‐HIAA as compared to controls, and this lack of relationship was replicated in 24 Caucasian alcoholics in the United States.