Open Access
Chemical composition along with antileishmanialand cytotoxic activity of Zatariamultiflora
Hossein Mahmoudvand,Shirzad Fallahi,Ebrahim Saedi Dezaki,Fariba Sharififar,Lianet Monzote,Fatemeh Ezatkhah +5 more
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TLDR
The chemical composition of Z. multiflora that might be a natural source of new anti-leishmanial agents in terms of use against cutaneous leishmaniasis is revealed.Abstract:
Context: Natural products and their compounds are some of the most interesting sources of new
drugs. Reviews have reported various pharmacological properties such as antimicrobial effects of
Zataria multiflora Boiss (Lamiaceae).
Objective: The present study investigates the chemical composition of Z. multiflora essential oil and
evaluates its cytotoxic effects and anti-leishmanial activities against Leishmania tropica in an in vitro
model.
Materials and methods: The components of Z. multiflora oil were identified by gas chromatography/
mass spectroscopy (GC/MS) analysis. Anti-leishmanial effects of the essential oil (0–100 mL/mL) and
methanol extract of Z. multiflora (0–100 mg/mL) on promastigote forms as well as their cytotoxic
activities against J774 cells were evaluated using MTT assay for 72 h. The leishmanicidal activity
against amastigote forms of L. tropica was evaluated at the concentrations of 0–50 mg/mL in a
macrophage model for 48 h.
Results: The chemical analyses demonstrated that the main components of essential oil were
thymol (41.81%), carvacrol (28.85%), and p-cymene (8.36%). Regarding leishmanicidal activity, the
IC50 values for the essential oil and methanol extract were 3.2 mL/mL and 9.8 mg/mL against
promastigote forms and 8.3 mL/mL and 34.6 mg/mL against amastigote forms, respectively. Essential
oil (CC50 89.3 mL/mL) indicated a higher cytotoxic effect than the methanol extract (CC50 591.6 mg/
mL) of Z. multiflora.
Conclusion: The present study revealed the chemical composition of Z. multiflora that might be a
natural source of new anti-leishmanial agents in terms of use against cutaneous leishmaniasisread more
Citations
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Trease and Evans' pharmacognosy
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In Vitro Control of Enterococcus faecalis by Zataria multiflora Boiss, Origanum vulgare L and Mentha pulegium Essential Oils
TL;DR: In this paper, the authors evaluated the antioxidant properties of the essential oils (EOs) from Zataria multiflora Boiss (ZMB), Origanum vulgare L (OVL) and Mentha pulegium (MP) and their influence on the growth, membrane permeability and cell surface characteristics of Enterococcus faecalis.
Journal ArticleDOI
Antiparasitic effects of Elettaria cardamomum L. essential oil and its main compounds, 1-8 Cineole alone and in combination with albendazole against Echinococcus granulosus protoscoleces
TL;DR: In this paper , the chemical structure and protoscolicidal effects of Elettaria cardamomum L. essential oil (ECEO) and its main compounds 1-8 cineole alone and along with albendazole (ALZ) against Echinococcus granulosus protoscoleces in vitro and ex vivo were determined.
Phytotherapy for Bacillus cereus: A review of the most important medicinal plants of Iran effective on B. cereus
TL;DR: The findings indicate that Eucalyptus camaldulensis Dehnh, Zataria multiflora, Mentha pulegium, Artemisia persica, Cuminum cyminum, Cordia myxa L, Scrophularia striata, mentha longifolia, Rosmarinus officinalis, and Lavandula sp.
Antileishmanial Activity of Myrtle Methanolic Extract against Leishmaniamajor: an In Vitro Study
Hossein Mahmoudvand,Hamed Salehi Lalehmarzi,Shirzad Fallahi,Maryam Moslehi Baharanchi,Pardis Bayat,Sareh Jahanbakhsh +5 more
TL;DR: The obtained results showed that myrtle extract was significantly inhibited promastigote growth of L. major based on a dose and time dependent manner.
References
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Linda C Tapsell,Ian Hemphill,Lynne Cobiac,Craig S Patch,David R. Sullivan,Michael Fenech,Steven Roodenrys,Jennifer B Keogh,Peter M. Clifton,Peter M. Clifton,Peter Williams,Virginia A Fazio,Karen E Inge +12 more
TL;DR: The role of herbs and spices in health benefits is discussed in this paper, where the authors consider the use of herbs as a source of antioxidants to combat oxidation in a healthy diet.
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