Journal ArticleDOI
Chemotherapy of Malaria
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This article is published in Journal of Parasitology.The article was published on 1987-08-01. It has received 269 citations till now. The article focuses on the topics: Malaria.read more
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New insights on the antiviral effects of chloroquine against coronavirus: what to expect for COVID-19?
TL;DR: The possible mechanisms of chloroquine interference with the SARS-CoV-2 replication cycle are discussed, which could lead to new therapies able to counter the most severe effects of the disease.
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Plasmodium vivax resistance to chloroquine
TL;DR: Two soldiers continued weekly prophylaxis with 300 mg chloroquine base on their return to Australia from Papua New Guinea but were not protected against Plasmodium vivax malaria, suggesting the emergence of strains of P v Vivax with a reduced susceptibility to chloroquines.
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Genetic mapping of the chloroquine-resistance locus on Plasmodium falciparum chromosome 7.
TL;DR: Inheritance data from 16 independent recombinant progeny show that the rapid efflux, chloroquine-resistant phenotype is governed by a single locus within an approximately 400-kilobase region of chromosome 7, and identification and characterization of genes within this region should lead to an understanding of the chlorquine-resistance mechanism.
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Beyond Chloroquine: Implications of Drug Resistance for Evaluating Malaria Therapy Efficacy and Treatment Policy in Africa
P B Bloland,Eve M. Lackritz,Peter N. Kazembe,J.B.O. Were,Richard W. Steketee,Carlos C. Campbell +5 more
TL;DR: Treatment with chloroquine can no longer be considered adequately effective therapy of clinical P. falciparum malaria in very young children in these areas of Africa.
Journal ArticleDOI
Pharmacokinetics of quinine, chloroquine and amodiaquine. Clinical implications.
TL;DR: Distribution rather than elimination processes determine the blood concentration profile of chloroquine in patients with acute malaria.