Journal ArticleDOI
Chitosan and chondroitin microspheres for oral-administration controlled release of metoclopramide
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TLDR
The kinetics of drug release from chitosan microspheres were best fitted by models originally developed for systems in which release rate is largely governed by rate of diffusion through the matrix.About:
This article is published in European Journal of Pharmaceutics and Biopharmaceutics.The article was published on 1999-09-01. It has received 105 citations till now. The article focuses on the topics: Controlled release & Drug carrier.read more
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Recent advances on chitosan-based micro- and nanoparticles in drug delivery.
TL;DR: The present review outlines the major new findings on the pharmaceutical applications of chitosan-based micro/nanoparticulate drug delivery systems published over the past decade and discusses critically the usefulness of these systems in delivering the bioactive molecules.
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Chitosan microspheres as a potential carrier for drugs
Vivek Ranjan Sinha,Anil K. Singla,S Wadhawan,R. Kaushik,Rachna Kumria,K. Bansal,Sanju Dhawan +6 more
TL;DR: This review is an insight into the exploitation of the various properties of chitosan to microencapsulate drugs and includes the factors that affect the entrapment efficiency and release kinetics of drugs from chitOSan microspheres.
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Polysaccharides in colon-specific drug delivery
Vivek Ranjan Sinha,Rachna Kumria +1 more
TL;DR: A large number of polysaccharides have already been studied for their potential as colon-specific drug carrier systems, such as chitosan, pectin, chondroitin sulphate, cyclodextrin, dextrans, guar gum, inulin, amylose and locust bean gum.
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Chitosan: some pharmaceutical and biological aspects--an update.
Anil K. Singla,Manish Chawla +1 more
TL;DR: Chitosan, a natural polysaccharide, is being widely used as a pharmaceutical excipient by the partial deacetylation of chitin, the second most abundant natural polymer.
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Chitosan-based nanomaterials: A state-of-the-art review
TL;DR: Chitosan based nanomaterials have superior physical and chemical properties such as high surface area, porosity, tensile strength, conductivity, photo-luminescent as well as increased mechanical properties as comparison to pure chitOSan.
References
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In vitro evaluation of mucoadhesive properties of chitosan and some other natural polymers
TL;DR: A number of natural or partially modified polymers were screened for muco-adhesive properties by routinely measuring the force of detachment for swollen polymer films from pig intestinal mucosa in a saline medium.
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Transit of pharmaceutical dosage forms through the small intestine.
S S Davis,J G Hardy,J W Fara +2 more
TL;DR: The gastrointestinal transit of pharmaceutical dosage forms has been measured in 201 studies in normal subjects using gamma scintigraphy and has implications for the design of dosage forms for the sustained release of drugs in specific positions in the gastrointestinal tract.
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Use of chitosan as a biomaterial: studies on its safety and hemostatic potential.
TL;DR: In vivo toxicity tests indicated that chitosan is nontoxic, and the sterilized films were free of pyrogen, and autoclaving appeared to be an ideal sterilizing method as it caused least decrease in tensile strength and effected a negligible rate of hemolysis.
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Metoclopramide. An updated review of its pharmacological properties and clinical use.
TL;DR: Metoclopramide has been confirmed as an effective drug in treating and preventing various types of vomiting and as a useful agent in oesophageal reflux disease, gastroparesis, dyspepsia, and in a variety of functional gastrointestinal disorders.
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Cross-linked chitosan microspheres: preparation and evaluation as a matrix for the controlled release of pharmaceuticals.
TL;DR: In‐vitro release studies of these drugs were carried out in simulated gastric and intestinal fluids at 37°C and it was observed that the drug release rates were influenced by the cross‐linking density, particle size and initial drug loading in the microspheres.