Journal ArticleDOI
Chondrocyte and chondrosarcoma cell integrins with affinity for collagen type ii and their response to mechanical stress
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TLDR
The collagen-binding integrins alpha 1 beta 1 and alpha 2 beta 1 isolated from bovine chondrocytes or human chondrosarcoma cells bound collagen type II as judged from affinity chromatography, and the effect of mechanical stress on expression of matrix molecules and integrin subunits was investigated.About:
This article is published in Experimental Cell Research.The article was published on 1995-12-01. It has received 102 citations till now. The article focuses on the topics: Integrin & Chondrocyte.read more
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Hydrogel properties influence ECM production by chondrocytes photoencapsulated in poly(ethylene glycol) hydrogels.
TL;DR: With the incorporation of degradable linkages into the network, gel properties with an initially high K (350 kPa) and final high q (7.9) were obtained, which allowed for increased type II collagen synthesis coupled with a homogenous distribution of GAGs.
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Cartilage tissue remodeling in response to mechanical forces.
TL;DR: The effects of mechanical loading on cartilage and the resulting chondrocyte-mediated biosynthesis, remodeling, degradation, and repair of this tissue are focused on.
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An introductory review of cell mechanobiology.
James H.-C. Wang,B P. Thampatty +1 more
TL;DR: Future research in the area of cell mechanobiology will require novel experimental and theoretical methodologies to determine the type and magnitude of the forces experienced at the cellular and sub-cellular levels and to identify the force sensors/receptors that initiate the cascade of cellular and molecular events.
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Articular cartilage functional histomorphology and mechanobiology: a research perspective
TL;DR: This hypothesis is supported by in vivo and ex vivo experiments where load-induced changes in matrix synthesis and catabolism, gene expression, and signal transduction pathways have been observed.
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Interaction of chondrocytes, extracellular matrix and growth factors: relevance for articular cartilage tissue engineering.
TL;DR: The role of the extracellular matrix in the regulation of chondrocyte function and the relevance for cartilage tissue engineering is discussed in this article, where structural matrix macromolecules (e.g. collagen, hyaluronate), but also growth factors (eg. IGF-I, TGF β) entrapped in the matrix and released under specific conditions affect chondroglyte behavior.