Showing papers in "Bone in 2003"

TL;DR: In conclusion, aging is associated with decreased proliferative capacity of osteoprogenitor cells, suggesting that decreased osteoblastic cell number, and not function, leads to age-related decrease in bone formation.

TL;DR: In conclusion, orthosilicic acid at physiological concentrations stimulates collagen type 1 synthesis in human osteoblast-like cells and enhances osteoblastic differentiation.

TL;DR: Hip fracture was a more common cause for mortality than pancreatic or stomach cancer and interventions that decreased hip fracture rate by, say, 50% would avoid 0.75% or more of all deaths.

TL;DR: Baseline vertebral fracture severity was the best independent predictor for new vertebral and nonvertebral fracture risk and remained a significant predictor after adjustment for baseline characteristics, including baseline BMD.

TL;DR: It is established that QCT-based "voxel" finite element models are better predictors of vertebral compressive strength than QCT measures of bone mineral density with or without measures of cross-sectional area and offers great promise for improvement of clinical fracture risk assessment.

TL;DR: Results demonstrate a direct effect of IL-8 on osteoclast differentiation and activity and implicate IL- 8 in the osteolysis associated with metastatic breast cancer.

TL;DR: It is shown for the first time that the signal transduction mechanism of shear stress in osteoblasts is complex and involves multiple ERK-dependent and independent pathways, and circumstantial evidence that there may be a PTX-sensitive pathway that has completing effects with an unknown pathway on the differentiation of normal human osteoblast.

TL;DR: This hypothesis is supported by in vivo and ex vivo experiments where load-induced changes in matrix synthesis and catabolism, gene expression, and signal transduction pathways have been observed.

TL;DR: Local application of antibiotic-coated orthopedic devices containing PDLLA and 10% gentamicin significantly reduced implant-related infection in this animal model.

TL;DR: It is found that some--but not all--previously reported clinical risk factors for skeletal fragility predicted all fragility fractures independently of BMD in healthy postmenopausal women, although they differed somewhat from those predicting specifically hip fractures in elderly women.

TL;DR: It is demonstrated that the male C57BL/6J mouse is a novel and appropriate model for use in studying endogenous, aging-related osteopenia and may be a useful model for the study of Type II osteoporosis.

TL;DR: In this article, the authors suggest that prevailing bone remodeling levels are substantially higher than are optimal for maintenance of bone strength and that such high remodeling is a major source of osteoporotic bony fragility.

TL;DR: Investigation of associations of serum adiponectin with BMD, FM, and serum leptin and soluble leptin receptor levels in 38 women and 42 men suggests that adiponECTin may play a role in the protective effects of visceral fat on BMD.

TL;DR: The results suggest that estrogen may exert its anti-resorptive effects on bone, at least in part, by stimulating ER and OPG expression in osteoblasts.

TL;DR: It was found that crystals were of platelet shape with irregular edges and that there was no substantial difference in crystal length or crystal thickness between normal and osteoporotic trabecular bone.

TL;DR: It can be suggested that changes in histomorphometric parameters of subchondral bone are secondary to cartilage damage and proceed deeper into subchONDral bone with increasing cartilage degeneration.

TL;DR: It is concluded that diagnostic transiliac biopsies can be used to determine the BMDD variables of cancellous bone for the entire skeleton of the patient, and qBEI provides a sensitive means to detect even small changes in mineralization due to bone disease or therapeutic intervention.

TL;DR: It is demonstrated that the effects of risedronate over 3 years on vertebral fracture and BMD are maintained with a further 2 years of treatment, as well as rapid and significant decreases in markers of bone turnover observed in the first 3 years were similarly maintained in the next 2 Years of treatment.

TL;DR: The mathematical model revealed that interactions among osteoblasts and osteoclasts result in complex, nonlinear system behavior, which cannot be deduced from studies of each cell type alone, and will be useful in future studies assessing the impact of cytokines, growth factors, and potential therapies on the overall process of remodeling in normal bone.

TL;DR: The results suggest that cyclic tension activates the Cbfa1/MMP-13 pathway and increases the expression of terminal differentiation hypertrophic markers.

TL;DR: There was no such "lag" between a more mechanically appropriate measure of body size and bone strength, and the results argue strongly for the importance of mechanical factors in the development of the preadult skeleton.

TL;DR: The risk of a subsequent vertebral fracture in individuals with preexisting deformities is importantly influenced by the characteristics of these deformities, including its shape and location in the spine.

TL;DR: Characteristics of apatite crystals in woven bone provide insight into the spatial and temporal relation between collagen and mineral that is the basis for the structure and organization of the mineral comprising human woven bone.

TL;DR: The pharmacokinetic profiles suggest that the anabolic or catabolic response of bone to PTH(1-34) is determined primarily by the length of time each day that serum concentrations of P TH remain above baseline levels of endogenous PTH and only secondarily by the Cmax or AUC achieved.

TL;DR: It is concluded that the COL1A1 Sp1 alleles are associated with a modest reduction in BMD and a significant increase in risk of osteoporotic fracture, particularly vertebral fracture.

TL;DR: Alkyl and heterocyclic NBPS suppressed bone resorption and FPPS/IPPI activity, and the antiresorptive effect of pamidronate was only partially reversible with GGOH, indicating the involvement of mechanism(s) of action additional to that of suppression of FPPS.

TL;DR: It is suggested that bone formation during distraction osteogenesis is accompanied by the robust induction of factors associated with angiogenesis and support further investigations to elucidate the mechanisms by which angiogenic events promote bone repair and regeneration.

TL;DR: Gender differences in hip structural analysis as they evolved over time in elderly white men and women are studied to identify candidate biological pathways leading to heightened risk of hip fracture and find Z is lower in women than in men and expansion of the proximal femur occurs in both sexes.

TL;DR: Alendronate is effective in increasing bone mass at the lumbar spine and femoral neck, while exercise iseffective in increasing the mechanical properties of bone at some of the most loaded bone sites, as well as improving the participants' muscular performance and dynamic balance.

TL;DR: The results show a significant increase of osteoprotegerin with age in healthy females and males but fluctuations do not predict bone mineral density under in vivo conditions.