Journal ArticleDOI
Chromosome study of Ewing's Sarcoma (ES) cell lines. Consistency of a reciprocal translocation t(11;22)(q24;q12)
Reads0
Chats0
TLDR
A detailed banded chromosome analysis was performed in five established Ewing's sarcoma cell lines originating from four unrelated patients in relapse, suggesting that t(11;22)(q24;q12) is a chromosomal change specific to ES cells, in which the rearranged chromosome #22 could be the consistent karyotypic feature and the crucial step in terms of cell proliferation.About:
This article is published in Cancer Genetics and Cytogenetics.The article was published on 1984-05-01. It has received 277 citations till now. The article focuses on the topics: Chromosomal translocation & Ewing's sarcoma.read more
Citations
More filters
Journal ArticleDOI
Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours
Olivier Delattre,Jessica Zucman,Béatrice Plougastel,Chantal Desmaze,Thomas Melot,Martine Peter,Heinrich Kovar,Isabelle Joubert,Pieter J. de Jong,Guy A. Rouleau,Alain Aurias,Gilles Thomas +11 more
TL;DR: Phylogenetically conserved restriction fragments in the vicinity of EWSR1 and EWSR2, the genomic regions where the breakpoints of chromosome 22 and chromosome 11 are, respectively, have allowed identification of transcribed sequences from these regions and has indicated that a hybrid transcript might be generated by the translocation.
Journal ArticleDOI
Bone sarcomas: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up
Paolo G. Casali,J.-Y. Blay +1 more
TL;DR: The following recommendations apply to adult-type soft tissue sarcomas arising from limbs and superficial trunk and Extraskeletal Ewing sarcoma, which is excluded from this chapter.
Journal ArticleDOI
Chromosome aberrations and cancer
TL;DR: The association of consistent chromosome aberrations with particular types of cancer has led to the identification of some of these genes and the elucidation of their mechanisms of action.
Journal ArticleDOI
Chromosomes in Ewing's sarcoma. I. An evaluation of 85 cases and remarkable consistency of t(11;22)(q24;q12)
C. Turc-Carel,Alain Aurias,Francine Mugneret,Sarab Lizard,Isabelle Sidaner,Christian Volk,Jean Paul Thiery,Sylviane Olschwang,Irène Philip,Marie Pierre Berger,Thierry Philip,Gilbert M. Lenoir,André Mazabraud +12 more
TL;DR: The standard t(11;22)(q24;q12) proved to be a remarkably consistent event, present in 83% of the cases, and the breakpoint on chromosome 22q12 appears to be the most consistently observed event.
Journal ArticleDOI
DNA-binding and transcriptional activation properties of the EWS-FLI-1 fusion protein resulting from the t(11;22) translocation in Ewing sarcoma.
R A Bailly,Rémy Bosselut,J Zucman,F Cormier,Olivier Delattre,M Roussel,G Thomas,Jacques Ghysdael +7 more
TL;DR: The results suggest that EWS-FLI-1 contributes to the transformed phenotype of ES tumor cells by inducing the deregulated and/or unscheduled activation of genes normally responsive to FLI- 1 or to other close members of the Ets family.
References
More filters
Journal Article
An international system for human cytogenetic nomenclature
TL;DR: An exceptional reading e-book entitled International System For Human Cytogenetic Nomenclature provides a thorough legal analysis and guidance to state authorities, human rights and humanitarian actors and others.
Journal ArticleDOI
Translocation of the c-myc gene into the immunoglobulin heavy chain locus in human Burkitt lymphoma and murine plasmacytoma cells
Rebecca Taub,Ilan R. Kirsch,Cynthia C. Morton,Gilbert M. Lenoir,D. Swan,Steven R. Tronick,Stuart A. Aaronson,Philip Leder +7 more
TL;DR: It is shown that transformation of human Burkitt lymphomas and murine plasmacytomas is frequently accompanied by the somatic rearrangement of a cellular analogue of an avian retrovirus transforming gene, c-myc, which provides a molecular basis for considering the role that specific translocations might play in malignant transformation.
Journal ArticleDOI
Translocation and Rearrangements of the c-myc Oncogene Locus in Human Undifferentiated B-Cell Lymphomas
TL;DR: It is shown in this study that the c- myc locus is rearranged in 5 out of 15 cell lines from patients with undifferentiated B-cell lymphomas, and that the rearrangement involves a region at the 5' side of an apparently intact c-myc gene.