Showing papers in "Cancer Genetics and Cytogenetics in 1988"

TL;DR: The standard t(11;22)(q24;q12) proved to be a remarkably consistent event, present in 83% of the cases, and the breakpoint on chromosome 22q12 appears to be the most consistently observed event.

TL;DR: The findings suggest that the primary karyotypic deviations of human medulloblastomas are gains of whole chromosomes, which are then either deleted or involved in unbalanced translocations, resulting in partial trisomies.

TL;DR: It is concluded that chromosome aberrations may be found in myomas of the uterus, and that t(12;14)(q14-15;q23-24) characterizes a subset of these tumors.

TL;DR: Consistent involvement of chromosome #16 in rearrangements with chromosome #1 may be an additional chromosome change specifically associated with ES.

TL;DR: Clonal karyotypic abnormalities in six of 12 cytogenetically investigated malignant fibrous histiocytomas reported had complex clonal chromosome aberrations, including ring chromosomes, dicentric chromosomes, and/or telomeric associations.

TL;DR: The chromosomes of nine consecutive human benign leiomyomas of the uterus were studied with banding methods following short-term culture and region 14q22-q24, which was involved in three specimens, may contain a DNA sequence critical for the genesis of uterineLeiomyoma.

TL;DR: Data support the view that the terminal region of 10q may harbor one or more genes involved in the early stages of melanocytic neoplasia.

TL;DR: The integration sites of human papillomavirus DNA within the cervical carcinoma cell line C4-I and a primary cervical tumor were mapped by in situ hybridization and appear to occur in the vicinity of fragile sites, oncogenes, and chromosome breakpoints that are characteristic of hematologic malignancies and solid tumors.

TL;DR: It is suggested that the breakpoints 9q31 and 22.q12.2 are associated with extraskeletal myxoid chondrosarcoma, a comparatively rare tumor of adulthood.

TL;DR: The karyotype contains deletions of both 7q and 10q, abnormalities that also have been described previously in prostatic adenocarcinomas, and which hence may represent primary chromosomal rearrangements in this type of cancer.

TL;DR: The in situ method for culturing amniocytes is modified and this new procedure is successfully used to culture cells from bone marrow, lymph nodes, peripheral blood, fibroblasts, and solid tumors.

TL;DR: Cytogenetic study of 30 bladder carcinomas confirmed the heterogeneity and the complexity of the karyotypic picture in this type of tumor.

TL;DR: Cytogenetic studies were performed on tumor cells from specimens of 30 consecutive patients with malignant pleural mesothelioma: karyotype findings were complex and heterogeneous: aneuploidy, polyploidsy, structural abnormalities, and several subclones were seen.

TL;DR: It is concluded that although many uterine myomas appear to have normal karyotypes, clonal chromosome abnormalities are present in some of these tumors.

TL;DR: In a series of 50 meningiomas, cytogenetic studies showed that almost half had a normal diploid karyotype, and the type of chromosome abnormalities seen were similar to those described for senescent human cell cultures, which suggests that common chromosome mechanisms may be operative in benign tumors and senescent cells.

TL;DR: Numerical deviations in these tumors involved mainly #14 by losses, and also #22; recurrent structural rearrangements involving 1p and 11p were also characteristic features, which could imply that involvement of #14, 1p, and 11P would be a form of clonal evolution secondary to monosomy 22 in certain meningiomas.

TL;DR: Fragile sites tend to be bands where breaks occur in cancer chromosome rearrangements that can involve oncogenes, and all were predominantly in light G bands, indicating that fragile sites may well be in light bands because they are associated with active genes.

TL;DR: The comparison of all the karyotypes established in each of 18 near-diploid colorectal tumors made it possible to reconstruct a clonal evolution and to distinguish between early and late chromosomal aberrations.

TL;DR: Although constitutional deletion of chromosome region 11p13 has frequently been reported to predispose to Wilms' tumor formation, only two tumors with deletions involving this region were observed.

TL;DR: Unfavorable prognostic factors associated with the risk of evolution into ANLL and with shorter overall survival were the presence of greater than 5% of bone marrow blasts, major chromosome abnormalities, and monosomy 7.

TL;DR: The large number of apparently unrelated abnormalities leads to suggest that the squamous cell carcinoma of the tongue may have been of multiclonal origin.

TL;DR: A reciprocal balanced translocation t(11;19)(q21;p13.1) as the sole clonal abnormality was found in the majority of metaphases, and the proliferation of epithelial cells was observed in the cultures, which should stimulate further efforts for cytogenetic investigations of the epithelial part.

TL;DR: The present results emphasize the importance of molecular studies of, in particular, the regions 8q12, 12q13-15, and 3p21, and the general characteristics of the aberrations observed in abnormal stemlines in both series agreed well.

TL;DR: The paper briefly discusses the binucleation-polyploidization as a possible compensatory mechanism to maintain the genetic balance in near-haploid cells.

TL;DR: The cytogenetics of 12 cases of renal adenocarcinoma showed that the chromosomal regions 3p11-p21, 1q21, 14q22, and Xp11 are important for the oncogenesis of renal cell carcinoma as well as increased dosage of chromosome #7 and loss or abnormalities of chromosomes #8 and #14.

TL;DR: Findings provide strong evidence suggesting that in Hodgkin's disease only the Reed-Sternberg cells possess a clonal karyotypic abnormality and thus are most probably the only neoplastic component in Hodgkins's disease.

TL;DR: The most favorable course of the disease was observed in the group of children with over 50 chromosomes in the leukemic cells, and patients with markers such as Ph, 6q-,14q+, and with a t(4;11) had a low incidence of complete remission and short survival.