Journal ArticleDOI
Clinical and cellular studies of sarcosinemia
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A child with sarcosinemia was studied in vivo by oral loading tests and in vitro by skin fibroblast cultures and short-term leukocyte incubations.About:
This article is published in The Journal of Pediatrics.The article was published on 1970-11-01. It has received 23 citations till now. The article focuses on the topics: Sarcosine dehydrogenase & Sarcosinemia.read more
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Labile methyl balances for normal humans on various dietary regimens.
S. Harvey Mudd,Jeffery R. Poole +1 more
TL;DR: It appears that methyl neogenesis must normally play a role in both males and females when labile methyl intake is curtailed, and de novo formation of methyl groups is quantitatively more significant than ingestion of preformed methyl moieties.
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Labile methyl group balances in the human: the role of sarcosine.
TL;DR: New data on methionine consumption due to sarcosine formation permit calculation of a turnover time for S-adenosylmethionine in human liver (no more than 3.5–7 min), as well as upward revision of previous minimal estimates of the rate of methylneogenesis, the number of times that the average homocysteinyl moiety cycles between methionsine and homocysteine during its passage through the body.
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Multiple Acyl-CoA Dehydrogenase Deficiency (Glutaric Aciduria Type II) with Transient Hypersarcosinemia and Sarcosinuria; Possible Inherited Deficiency of an Electron Transfer Flavoprotein
TL;DR: The authors conclude that this disorder is not due to generalized deficiency of glutaryl-CoA dehydrogenase or to a defect in FAD synthesis, and that the presence of hypersarcosinemia and/or sarcosinuria may delineate a subtype due to deficiency of an electron carrier flavoprotein.
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Hereditary transcobalamin II deficiency: The role of transcobalamin II in vitamin B12-mediated reactions
TL;DR: The data suggest that the presence of TC II is necessary for normal cellular maturation of the hematopoietic system, but TC II may not be essential for the delivery of methyl-B 12 or 5′-deoxyadenosyl- B 12 for metabolic activity.
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Endogenous formaldehyde is a memory-related molecule in mice and humans
Li Ai,Tao Tan,Yonghe Tang,Jun Yang,Dehua Cui,Rui Wang,Aibo Wang,Xuechao Fei,Yalan Di,Xiaoming Wang,Yan Yu,Shengjie Zhao,Weishan Wang,Shangying Bai,Shangying Bai,Xu Yang,Rongqiao He,Rongqiao He,Weiying Lin,Hongbin Han,Xiang Cai,Zhiqian Tong +21 more
TL;DR: It is reported that under physiological conditions, spatial learning activity elicits rapid formaldehyde generation from mitochondrial sarcosine dehydrogenase (SARDH) and it is concluded that endogenous formaldehyde regulates learning and memory via the NMDA receptor.
References
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Automatic recording apparatus for use in the chromatography of amino acids.
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A simple efficient liquid scintillator for counting aqueous solutions in a liquid scintillation counter
TL;DR: A modification of the naphthalene-dioxane-PPO liquid scintillator has been described which will allow up to 3.0 ml of an aqueous solution to be counted as mentioned in this paper.
Book
Chromatographic and electrophoretic techniques
TL;DR: The reviewer was left with the impression that more attention is paid to these tests in the author's departments than is usually done in Great Britain.
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Diagnosis of Gaucher's Disease and Niemann-Pick Disease with Small Samples of Venous Blood
TL;DR: Enzymes which catalyze the hydrolysis of glucocerebroside and sphingomyelin have been demonstrated in preparations of washed human white blood cells and may be useful in the differential diagnosis of the sphingolipidoses.