Clinical presentation and diagnostic approach in cases of genitourinary tuberculosis
TLDR
GUTB can involve any part of the genitourinary system and presentation may vary from vague urinary symptoms to chronic kidney disease, and newer tests like radiometric liquid culture systems and polymerase chain reaction give rapid results and carry high diagnostic value.Citations
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Tuberculosis of the genitourinary system-Urinary tract tuberculosis: Renal tuberculosis-Part II
TL;DR: Well- known complications of GUTB such as sinus tracts, fistulae and amyloidosis are described, along with the relatively less well-known complications such as tuberculous interstitial nephritis (TIN), which may remain hidden because of its ‘culture negative’ nature and thus lead to renal failure.
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Anti-tubercular therapy for intraocular tuberculosis: A systematic review and meta-analysis
Ae Ra Kee,Julio J. González-López,Aws Al-Hity,Bhaskar Gupta,Cecilia S Lee,Dinesh Visva Gunasekeran,Nirmal Jayabalan,Robert Grant,Onn Min Kon,Vishali Gupta,Mark Westcott,Carlos Pavesio,Rupesh Agrawal,Rupesh Agrawal,Rupesh Agrawal +14 more
TL;DR: The use of ATT may be of benefit to patients with suspected intraocular tuberculosis; however, this conclusion is limited by the lack of control group analysis and standardized recruitment and treatment protocols.
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Genital tuberculosis: current status of diagnosis and management
TL;DR: Most patients with tubercular epididymo-orchitis respond to antitubercular therapy but may require open or percutaneous drainage, and regular annual follow up is recommended even though, with the current multi drug therapy, the chances of relapse are low.
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Urogenital tuberculosis - epidemiology, pathogenesis and clinical features.
TL;DR: Patients who have had a renal transplant, have HIV infection, receive immunosuppressive therapies, have diabetes, have COPD and those undergoing dialysis often experience reactivation of latent TB infection.
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Diagnostic accuracy of nucleic acid amplification tests (NAATs) in urine for genitourinary tuberculosis: a systematic review and meta-analysis.
Carlos Altez-Fernandez,Victor Ortiz,Majid Mirzazadeh,Luis Zegarra,Carlos Seas,Carlos Seas,Cesar Ugarte-Gil +6 more
TL;DR: A systematic review and meta-analysis of research articles comparing the accuracy of a reference standard and a nucleic acid amplification test for diagnosis of urinary tract tuberculosis found PCR studies were highly heterogeneous, however among Xpert MTB/RIF studies, specificity was favorable with an acceptable confidence interval.
References
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Genital tuberculosis in Indian infertility patients.
TL;DR: A combination of clinical and laparoscopic diagnoses, along with endometrial histopathologic studies, acid‐fast bacillus culture, and polymerase chain reaction assays provides the best available method for the diagnosis of genital tuberculosis in infertile women.
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Polymerase chain reaction in clinically suspected genitourinary tuberculosis : comparison with intravenous urography, bladder biopsy, and urine acid fast bacilli culture
TL;DR: It is evident from this series that PCR provides a much faster diagnosis of urinary MTb and is a rapid, sensitive, and specific diagnostic method and avoids a delay in starting treatment.
Journal Article
Newer diagnostic techniques for tuberculosis.
TL;DR: Gene amplification methods (PCR as well as isothermal) developed for diagnosis of tuberculosis are demonstrably highly sensitive specially in culture negative specimens from different paucibacillary forms of disease.
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Genitourinary manifestations of tuberculosis.
TL;DR: By the 1980s, the availability of antituberculosis chemotherapy reduced the incidence and prevalence of tuberculosis and changing patterns of population emigration and the development of large pools of immune-compromised individuals reversed the downward trend of tuberculosis.
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Comparison of the conventional diagnostic modalities, bactec culture and polymerase chain reaction test for diagnosis of tuberculosis.
TL;DR: PCR test sensitivity in pulmonary and extrapulmonary clinical samples were 72.7% and 75.9% respectively and found to be significantly higher (P< 0.05) when compared with those of other tests.