Open Access
clinicalinvestigations Bronchoalveolar Lavage of Allergic Asthmatic Patients following Allergen Bronchoprovocation
Reads0
Chats0
TLDR
The studies show that in carefully selected, mildly symptomatic asthmatic subjects, BPC and BAL may be useful to evaluate pathogenetic mechanisms in allergic bronchial asthma.About:
The article was published on 2017-01-01 and is currently open access. It has received 273 citations till now. The article focuses on the topics: Bronchoalveolar lavage & Allergen.read more
Citations
More filters
Journal ArticleDOI
Mucosal inflammation in asthma.
Ratko Djukanovic,William R. Roche,John W Wilson,C. R. W. Beasley,Orion P. Twentyman,P H Howarth,Stephen T. Holgate +6 more
TL;DR: It is not possible to relate precisely the findings obtained by bronchoscopy to the clinical presentation and progression of asthma, but direct evidence obtained from allergen challenge leading to increased bronchial hyperresponsiveness during LAR, and direct evidence of inflammatory cells and their mediators in the airway mucosa and lumen after allergenic challenge argue for an active role of cells in bringing about inflammatory changes.
Journal ArticleDOI
Immunologic basis of antigen-induced airway hyperresponsiveness
TL;DR: Current understanding of the pathophysiologic mechanisms by which Th2 cytokines induce airway disease, and the factors that predispose to the generation of these pathogenic cells in response to inhalation of ubiquitous aero-allergens are discussed.
Journal ArticleDOI
Effect of an inhaled corticosteroid on airway inflammation and symptoms in asthma.
Ratko Djukanovic,John W Wilson,KM Britten,Susan J. Wilson,Andrew F. Walls,William R. Roche,Peter H. Howarth,Stephen T. Holgate +7 more
TL;DR: It is suggested that the beneficial effect of inhaled corticosteroids in asthma may be attributed to their antiinflammatory action in the bronchial mucosa.
Journal ArticleDOI
Sudden-Onset Fatal Asthma: A Distinct Entity with Few Eosinophils and Relatively More Neutrophils in the Airway Submucosa?
Sanjiv Sur,Thomas B. Crotty,Gail M. Kephart,Bruce A. Hyma,Thomas V. Colby,Charles E. Reed,Loren W. Hunt,Gerald J. Gleich +7 more
TL;DR: Sudden-onset fatal asthma is suggested to be immunohistologically distinct from slow-onsett fatal asthma and that it is characterized by a relative paucity of eosinophil in the face of an excess of neutrophils in the airway submucosa.
References
More filters
Journal ArticleDOI
Standardization of bronchial inhalation challenge procedures
Hyman Chai,Richard S. Farr,Luz A. Froehlich,David A. Mathison,James A. McLean,Richard R. Rosenthal,Albert L. Sheffer,Sheldon L. Spector,Robert G. Townley +8 more
TL;DR: Criteria for procedures and materials used were suggested in order to standardize bronchial inhalation challenges as they pertain to allergic disease.
Journal ArticleDOI
Bronchoalveolar eosinophilia during allergen-induced late asthmatic reactions.
TL;DR: Bronchoalveolar lavage was performed in 19 asthmatic patients and in 5 control subjects to suggest that eosinophils and their mediators might be involved in the development of LAR after allergen inhalation.
Journal ArticleDOI
Identification by immunofluorescence of eosinophil granule major basic protein in lung tissues of patients with bronchial asthma
TL;DR: Tests suggest that MBP in the eosinophil granule is released into respiratory tissue of patients with severe asthma and that it is associated with tissue damage.
Journal Article
Cytotoxic effects of the guinea pig eosinophil major basic protein on tracheal epithelium.
Elevated levels of the eosinophil granule major basic protein in the sputum of patients with bronchial asthma
TL;DR: It is found that eosinophil granule constituents are released into the bronchi in asthma and that measurement of sputum MBP may be useful in identifying asthma.