Citations
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Genetic susceptibility to asthma--bronchial hyperresponsiveness coinherited with a major gene for atopy.
Dirkje S. Postma,Eugene R. Bleecker,PJ Amelung,Kenneth J. Holroyd,Jianfeng Xu,Carolien I.M. Panhuysen,Deborah A. Meyers,Roy C. Levitt +7 more
TL;DR: It is demonstrated that a trait for an elevated level of serum total IgE is coinherited with a traits for bronchial hyperresponsiveness and that a gene governing bronchiahyperresponsiveness is located near a major locus that regulates serum IgE levels on chromosome 5q.
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The role of histamine H1 and H4 receptors in allergic inflammation: the search for new antihistamines
TL;DR: Accumulating evidence is reviewed suggesting that histamine indeed has roles in inflammation and immune function modulation in such diseases and a possible synergy between H1 and H4-receptor antagonists in targeting various inflammatory conditions is reviewed.
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Activated T cells and eosinophilia in bronchoalveolar lavages from subjects with asthma correlated with disease severity.
TL;DR: A close correlation between T cell activation, eosinophilia, and severity of asthma is demonstrated, suggesting that recruitment and activation of lymphocytes and EOSs are fundamental to the pathogenesis of bronchial asthma.
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Expression of Interleukin 9 in the Lungs of Transgenic Mice Causes Airway Inflammation, Mast Cell Hyperplasia, and Bronchial Hyperresponsiveness
TL;DR: Physiologic evaluation of IL-9–expressing mice demonstrated normal baseline airway resistance and markedly increased airway hyperresponsiveness to inhaled methacholine, suggesting an important role for IL- 9 in the pathogenesis of asthma.
References
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Journal ArticleDOI
TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties.
Tim R. Mosmann,R L Coffman +1 more
TL;DR: Two types of cloned helper T cells are described, defined primarily by differences in the pattern of lymphokines ynthesized, and the different functions of the two types of cells and their lymphokine synthesis are discussed.
Journal Article
Induction by IL 1 and interferon-gamma: tissue distribution, biochemistry, and function of a natural adherence molecule (ICAM-1).
TL;DR: Staining of frozen sections and immunofluorescence flow cytometry showed intercellular adhesion molecule-1 (ICAM-1) is expressed on non-hematopoietic cells such as vascular endothelial cells, thymic epithel cells, certain other epithelial Cells, and fibroblasts, and on hematopOietic Cells such as tissue macrophages, mitogen-stimulated T lymphocyte blasts, and germinal center dendritic
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Association of asthma with serum IgE levels and skin-test reactivity to allergens.
TL;DR: It is concluded that asthma is almost always associated with some type of IgE-related reaction and therefore has an allergic basis, although not all the allergic stimuli that cause asthma appear to have been included in the battery of common aeroallergens the authors used to assess atopic status.
Journal Article
A human intercellular adhesion molecule (icam-1) distinct from lfa-1
TL;DR: It is proposed that ICAM-1 may be a ligand in many, but not all, LFA-1-dependent adhesion reactions.
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Damage of the airway epithelium and bronchial reactivity in patients with asthma.
TL;DR: In this paper, the authors measured bronchial reactivity to inhaled histamine and prepared electron micrographs from 8 asthmatic patients who never smoked (2 females, 6 males, 18 to 62 yr of age).