Journal ArticleDOI
Coenzyme Q-10 in Human Health: Supporting Evidence?
Sibu P. Saha,Thomas F. Whayne +1 more
TLDR
Coenzyme Q-10 (CoQ10) is a widely used alternative medication or dietary supplement and one of its roles is as an antioxidant as mentioned in this paper, it naturally functions as a coenzyme and component of oxidative phosphorylation in mitochondria.Abstract:
Coenzyme Q-10 (CoQ10) is a widely used alternative medication or dietary supplement and one of its roles is as an antioxidant. It naturally functions as a coenzyme and component of oxidative phosphorylation in mitochondria. Decreased levels have been demonstrated in diseased myocardium and in Parkinson disease. Farnesyl pyrophosphate is a critical intermediate for CoQ10 synthesis and blockage of this step may be important in statin myopathy. Deficiency of CoQ10 also has been associated with encephalomyopathy, severe infantile multisystemic disease, cerebellar ataxia, nephrotic syndrome, and isolated myopathy. Although supplementation with CoQ10 has been reported to be beneficial in treating hypertension, congestive heart failure, statin myopathy, and problems associated with chemotherapy for cancer treatement, this use of CoQ10 as a supplement has not been confirmed in randomized controlled clinical trials. Nevertheless, it appears to be a safe supplementary medication where usage in selected clinical situations may not be inappropriate. This review is an attempt to actualize the available information on CoQ10 and define its potential benefit and appropriate usage.read more
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Book ChapterDOI
Mitochondria Damage and Kidney Disease.
Pu Duann,Pei-Hui Lin +1 more
TL;DR: Kidney diseases, either acute kidney injury (AKI) or chronic kidney disease (CKD), are important clinical issues and global public health concerns with high mortality rate and socioeconomic burden due to lack of effective therapeutic strategies to cure or retard the progression of the diseases.
Journal ArticleDOI
Effects of statins on mitochondrial pathways.
Hamid Mollazadeh,Erfan Tavana,Giovanni Fanni,Simona Bo,Maciej Banach,Maciej Banach,Matteo Pirro,Stephan von Haehling,Tannaz Jamialahmadi,Tannaz Jamialahmadi,Amirhossein Sahebkar +10 more
TL;DR: In this paper, the authors report the mechanisms of action of statins on mitochondrial function and find that statins have several effects on mitochondria including reduction of coenzyme Q10 level, inhibition of respiratory chain complexes, induction of mitochondrial apoptosis, dysregulation of Ca2+ metabolism, and carnitine palmitoyltransferase-2 expression.
Journal ArticleDOI
Familial Hypercholesterolemia: New Horizons for Diagnosis and Effective Management.
TL;DR: This review presents a comprehensive overview of the pathophysiology, epidemiology, manifestations, and pharmacological treatment of FH, whilst summarizing the up-to-date relevant recommendations and guidelines.
Journal ArticleDOI
Coenzyme Q10 inhibits the activation of pancreatic stellate cells through PI3K/AKT/mTOR signaling pathway.
TL;DR: The finding suggests that CoQ10 inhibits the activation of PSCs by suppressing autophagy through activating the PI3K/AKT/mTOR signaling pathway and may act as a therapeutic agent in PSC-relating pathologies and/or anti-fibrotic approaches.
Journal ArticleDOI
Short‐term ubiquinol supplementation reduces oxidative stress associated with strenuous exercise in healthy adults: A randomized trial
Alvaro Sarmiento,Javier Díaz-Castro,Mario Pulido-Moran,Jorge Moreno-Fernandez,Naroa Kajarabille,I.J. Chirosa,Isabel M. Guisado,Luis Javier Chirosa,Rafael Guisado,Julio J. Ochoa +9 more
TL;DR: A short-term supplementation (2 weeks) with Ubiquinol (200 mg/day) before strenuous exercise, decreases oxidative stress and increases plasma NO, fact that could improve endothelial function, energetic substrate supply, and muscle recovery after strenuous Exercise.
References
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Journal ArticleDOI
Trends in Alternative Medicine Use in the United States, 1990-1997 Results of a Follow-up National Survey
David Eisenberg,Roger B. Davis,Susan L. Ettner,Scott Appel,Sonja Wilkey,Maria I. Van Rompay,Ronald C. Kessler +6 more
TL;DR: Alternative medicine use and expenditures increased substantially between 1990 and 1997, attributable primarily to an increase in the proportion of the population seeking alternative therapies, rather than increased visits per patient.
Journal ArticleDOI
The role of coenzyme Q10 in statin-associated myopathy: a systematic review.
TL;DR: It is concluded that there is insufficient evidence to prove the etiologic role of CoQ10 deficiency in statin-associated myopathy and that large, well-designed clinical trials are required to address this issue.
Journal ArticleDOI
Coenzyme Q10: absorption, tissue uptake, metabolism and pharmacokinetics.
Hemmi N. Bhagavan,Raj K. Chopra +1 more
TL;DR: Animal data show that CoQ10 in large doses is taken up by all tissues including heart and brain mitochondria, which has implications for therapeutic applications in human diseases and there is evidence for its beneficial effect in cardiovascular and neurodegenerative diseases.
Journal ArticleDOI
Effect of coenzyme q10 on myopathic symptoms in patients treated with statins.
TL;DR: Results suggest that coenzyme Q10 supplementation may decrease muscle pain associated with statin treatment, and may offer an alternative to stopping treatment with these vital drugs.
Journal ArticleDOI
Coenzyme Q10: An Independent Predictor of Mortality in Chronic Heart Failure
Sarah L. Molyneux,Christopher M. Florkowski,Peter M. George,Anna P. Pilbrow,Chris Frampton,Michael Lever,A. Mark Richards +6 more
TL;DR: Plasma CoQ(10) concentration was an independent predictor of mortality in this cohort and might be detrimental to the long-term prognosis of CHF, and there is a rationale for controlled intervention studies with Co Q(10.