Cold acclimation recruits human brown fat and increases nonshivering thermogenesis
Anouk A.J.J. van der Lans,Joris Hoeks,Boudewijn Brans,Guy H. E. J. Vijgen,Mariëlle G. W. Visser,Maarten J. Vosselman,Jan Hansen,Johanna A. Jörgensen,Jun Wu,Felix M. Mottaghy,Patrick Schrauwen,Wouter D. van Marken Lichtenbelt +11 more
TLDR
It is shown that a 10-day cold acclimation protocol in humans increases BAT activity in parallel with an increase in nonshivering thermogenesis (NST) and may contribute to counteracting the current obesity epidemic.Abstract:
In recent years, it has been shown that humans have active brown adipose tissue (BAT) depots, raising the question of whether activation and recruitment of BAT can be a target to counterbalance the current obesity pandemic. Here, we show that a 10-day cold acclimation protocol in humans increases BAT activity in parallel with an increase in nonshivering thermogenesis (NST). No sex differences in BAT presence and activity were found either before or after cold acclimation. Respiration measurements in permeabilized fibers and isolated mitochondria revealed no significant contribution of skeletal muscle mitochondrial uncoupling to the increased NST. Based on cell-specific markers and on uncoupling protein-1 (characteristic of both BAT and beige/brite cells), this study did not show “browning” of abdominal subcutaneous white adipose tissue upon cold acclimation. The observed physiological acclimation is in line with the subjective changes in temperature sensation; upon cold acclimation, the subjects judged the environment warmer, felt more comfortable in the cold, and reported less shivering. The combined results suggest that a variable indoor environment with frequent cold exposures might be an acceptable and economic manner to increase energy expenditure and may contribute to counteracting the current obesity epidemic.read more
Citations
More filters
Journal ArticleDOI
What We Talk About When We Talk About Fat
TL;DR: New perspective is gained on the roles played by adipocyte in a variety of homeostatic processes and on the mechanisms used by adipocytes to communicate with other tissues and how these relationships are altered during metabolic disease and how they might be manipulated to restore metabolic health.
Journal ArticleDOI
Adipose tissue browning and metabolic health
Alexander Bartelt,Joerg Heeren +1 more
TL;DR: Stimulating the development of beige adipocytes in WAT (so called 'browning') might reduce adverse effects of WAT and could help to improve metabolic health, as well as inspire new avenues to increase the capacity for adaptive thermogenesis.
Journal ArticleDOI
Activation of Human Brown Adipose Tissue by a β3-Adrenergic Receptor Agonist
Aaron M. Cypess,Lauren S Weiner,Carla Roberts-Toler,Elisa F. Elia,Skyler H. Kessler,Peter A. Kahn,Jeffrey English,Kelly Chatman,Sunia A. Trauger,Alessandro Doria,Gerald M. Kolodny +10 more
TL;DR: A β3-AR agonist can stimulate human BAT thermogenesis and may be a promising treatment for metabolic disease.
Journal ArticleDOI
Eosinophils and type 2 cytokine signaling in macrophages orchestrate development of functional beige fat
Yifu Qiu,Khoa D. Nguyen,Justin I. Odegaard,Xiaojin Cui,Xiao Yu Tian,Richard M. Locksley,Richard D. Palmiter,Ajay Chawla +7 more
TL;DR: The efferent circuit controlling biogenesis of beige fat is uncovered and support for its targeting to treat obesity is provided.
Journal ArticleDOI
Brown and Beige Fat: Physiological Roles beyond Heat Generation.
TL;DR: This work aims to discuss recent insights regarding the developmental lineages, molecular regulation, and new functions for brown and beige adipocytes.
References
More filters
Journal ArticleDOI
Brown Adipose Tissue: Function and Physiological Significance
Barbara Cannon,Jan Nedergaard +1 more
TL;DR: The development of brown adipose tissue with its characteristic protein, uncoupling protein-1 (UCP1), was probably determinative for the evolutionary success of mammals, as its thermogenesis enhances neonatal survival and allows for active life even in cold surroundings.
Journal ArticleDOI
Identification and Importance of Brown Adipose Tissue in Adult Humans
AM Cypess,Sanaz Lehman,Gethin Williams,Ilan Tal,Dean Rodman,Allison B. Goldfine,FC Kuo,Edwin L. Palmer,Yu-Hua Tseng,Alessandro Doria,Gerald M. Kolodny,C R Kahn +11 more
TL;DR: Defined regions of functionally active brown adipose tissue are present in adult humans, are more frequent in women than in men, and may be quantified noninvasively with the use of (18)F-FDG PET-CT.
Journal ArticleDOI
Graphical Evaluation of Blood-to-Brain Transfer Constants from Multiple-Time Uptake Data:
TL;DR: A theoretical model of blood–brain exchange is developed and a procedure is derived that can be used for graphing multiple-time tissue uptake data and determining whether a unidirectional transfer process was dominant during part or all of the experimental period.
Journal ArticleDOI
Cold-activated brown adipose tissue in healthy men.
Wouter D. van Marken Lichtenbelt,Joost W. Vanhommerig,Nanda M Smulders,Jamie Drossaerts,Gerrit J. Kemerink,Nicole D. Bouvy,Patrick Schrauwen,G J Jaap Teule +7 more
TL;DR: Brown adipose tissue may be metabolically important in men, and the fact that it is reduced yet present in most overweight or obese subjects may make it a target for the treatment of obesity.
Journal ArticleDOI
Functional brown adipose tissue in healthy adults.
Kirsi A. Virtanen,Martin E. Lidell,Janne Orava,Mikael Heglind,Rickard Westergren,Tarja Niemi,Markku Taittonen,Jukka Laine,Nina-Johanna Savisto,Sven Enerbäck,Pirjo Nuutila +10 more
TL;DR: These findings document the presence of substantial amounts of metabolically active brown adipose tissue in healthy adult humans.