K
Khoa D. Nguyen
Researcher at Nanyang Technological University
Publications - 169
Citations - 9412
Khoa D. Nguyen is an academic researcher from Nanyang Technological University. The author has contributed to research in topics: Encryption & Group signature. The author has an hindex of 33, co-authored 161 publications receiving 7983 citations. Previous affiliations of Khoa D. Nguyen include Stanford University & University of Hamburg.
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Journal ArticleDOI
Macrophage-mediated inflammation in metabolic disease
TL;DR: This work focuses on the pathogenic and protective functions of classically and alternatively activated macrophages, respectively, in experimental models of obesity and metabolic disease, in order to clarify the role of these cells in metabolic homeostasis.
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Functional cortical neurons and astrocytes from human pluripotent stem cells in 3D culture
Anca M. Pasca,Steven A. Sloan,Laura E. Clarke,Yuan Tian,Christopher D. Makinson,Nina Huber,Chul Hoon Kim,Jin-Young Park,Nancy A. O'Rourke,Khoa D. Nguyen,Stephen J. Smith,John R. Huguenard,Daniel H. Geschwind,Ben A. Barres,Sergiu P. Paşca +14 more
TL;DR: A simple and reproducible 3D culture approach for generating a laminated cerebral cortex–like structure, named human cortical spheroids (hCSs), from pluripotent stem cells, which demonstrate that cortical neurons participate in network activity and produce complex synaptic events.
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Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis
Khoa D. Nguyen,Yifu Qiu,Xiaojin Cui,Y. P. Sharon Goh,Y. P. Sharon Goh,Julia W. Mwangi,Tovo David,Lata Mukundan,Frank Brombacher,Richard M. Locksley,Ajay Chawla +10 more
TL;DR: A role for alternatively activated macrophages is discovered in the orchestration of an important mammalian stress response, the response to cold, as reported in mice.
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Eosinophils and type 2 cytokine signaling in macrophages orchestrate development of functional beige fat
Yifu Qiu,Khoa D. Nguyen,Justin I. Odegaard,Xiaojin Cui,Xiao Yu Tian,Richard M. Locksley,Richard D. Palmiter,Ajay Chawla +7 more
TL;DR: The efferent circuit controlling biogenesis of beige fat is uncovered and support for its targeting to treat obesity is provided.
Journal ArticleDOI
Signaling by IL-6 promotes alternative activation of macrophages to limit endotoxemia and obesity-associated resistance to insulin
Jan Mauer,Bhagirath Chaurasia,Julia Goldau,Merly C. Vogt,Johan Ruud,Khoa D. Nguyen,Sebastian Theurich,A. Christine Hausen,Joel Schmitz,Hella S. Brönneke,Emma Estevez,Tamara L Allen,Andrea Mesaros,Linda Partridge,Mark A. Febbraio,Ajay Chawla,F. Thomas Wunderlich,Jens C. Brüning +17 more
TL;DR: The results identify signaling via IL-6 as an important determinant of the alternative activation of macrophages and assign an unexpected homeostatic role to IL- 6 in limiting inflammation.