Combination of Quinupristin-Dalfopristin (Synercid) and Rifampin Is Highly Synergistic in Experimental Staphylococcus aureus Joint Prosthesis Infection
Azzarn Saleh-Mghir,Nourdine Ameur,Claudette Muller-Serieys,Farid Ismael,Francoise Lemaitre,L. Massias,Célinc Feger,Rémy Bleton,Anne-Claude Cremieux +8 more
TLDR
Q-D significantly reduced the mean log10 CFU per gram of bone versus that for the controls, and the combination of rifampin with either Q-D or vancomycin was significantly more effective than monotherapy.Abstract:
We compared the efficacies of quinupristin-dalfopristin (Q-D; 30 mg/kg of body weight every 8 h) and vancomycin (60 mg/kg twice daily), alone or in combination with rifampin (10 mg/kg twice daily), in a rabbit model of methicillin-resistant Staphylococcus aureus knee prosthesis infection. In contrast to vancomycin, Q-D significantly reduced the mean log10 CFU per gram of bone versus that for the controls. The combination of rifampin with either Q-D or vancomycin was significantly more effective than monotherapy.read more
Citations
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Antibiotic treatment of gram-positive bone and joint infections.
TL;DR: Different degrees of bone penetration and clinical outcome for specific antibiotics, e.g. the beta-lactams, clindamycin and quinolones, have been described, although the methodology in these studies is not standardized and findings cannot be applied directly to patients.
Journal ArticleDOI
Foreign body infections due to Staphylococcus epidermidis.
TL;DR: The pathogenesis, prevention, and treatment of implant infections due to S. epidermidis are reviewed and some new compounds with already promising in vitro results are highlighted.
Journal ArticleDOI
Antimicrobial agents in orthopaedic surgery: Prophylaxis and treatment.
Andrej Trampuz,Werner Zimmerli +1 more
TL;DR: Treatment of infections associated with orthopaedic devices usually requires appropriate surgical intervention combined with prolonged antimicrobial therapy, and the choice of the antimicrobial regimen depends on the duration and pathogenesis of infection, stability of the implant, antimicrobial susceptibility of the pathogen and condition of the surrounding soft tissue.
Journal ArticleDOI
Rifampin Combination Therapy for Nonmycobacterial Infections
TL;DR: Rifampin combination therapy appears to have improved treatment outcomes in cases in which there is a low organism burden, but is less effective when effective surgery to obtain source control is not performed, and needs further exploration for these severe MRSA infections.
Journal ArticleDOI
Adjunctive use of rifampin for the treatment of Staphylococcus aureus infections: a systematic review of the literature
TL;DR: In vitro results of interactions between rifampin and other antibiotics are method dependent and often do not correlate with in vivo findings, while adjunctive therapy seems most promising for the treatment of osteomyelitis and prosthetic device-related infections.
References
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Emergence of Vancomycin Resistance in Staphylococcus aureus
Theresa L. Smith,Michele L. Pearson,Kenneth R. Wilcox,Cosme Cruz,Michael V. Lancaster,Barbara Robinson-Dunn,Fred C. Tenover,Marcus J. Zervos,Jeffrey D. Band,Elizabeth M. White,William R. Jarvis +10 more
TL;DR: In this article, the authors investigated the two patients with infections due to S. aureus with intermediate resistance to glycopeptides, as defined by a minimal inhibitory concentration of vancomycin of 8 to 16 μg per milliliter.
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Role of Rifampin for Treatment of Orthopedic Implant–Related Staphylococcal Infections : A Randomized Controlled Trial
TL;DR: Among patients with stable implants, short duration of infection, and initial debridement, patients able to tolerate long-term therapy with rifampin-ciprofloxacin experienced cure of the infection without removal of the implant.
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Bacterial Pathogens Isolated from Patients with Bloodstream Infection: Frequencies of Occurrence and Antimicrobial Susceptibility Patterns from the SENTRY Antimicrobial Surveillance Program (United States and Canada, 1997)
TL;DR: Overall, U.S. isolates were considerably more resistant than those from Canada, and distinct differences were noted in the antimicrobial susceptibilities of several pathogens.