Journal ArticleDOI
Comparative analysis of Staphylococcus epidermidis strains utilizing quantitative and cell surface shaving proteomics
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TLDR
These proteins show RP62A maintains an active CRISPR-mediated defense, as well as heightened antibiotic resistance in comparison to a non-virulent, non-biofilm forming strain, and may be useful vaccine antigens in clinical settings if administered in at-risk patients prior to surgical implantations.About:
This article is published in Journal of Proteomics.The article was published on 2016-01-01. It has received 18 citations till now. The article focuses on the topics: Biofilm matrix & Staphylococcus epidermidis.read more
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Antibacterial activity of the non-cytotoxic peptide (p-BthTX-I)2 and its serum degradation product against multidrug-resistant bacteria
Norival A. Santos-Filho,R.S. Fernandes,Bruna F. Sgardioli,Matheus Aparecido dos Santos Ramos,Julia Pinto Piccoli,Ilana Lopes Baratella da Cunha Camargo,Taís Maria Bauab,Eduardo Maffud Cilli +7 more
TL;DR: The results demonstrated that both peptides analyzed and the product of proteolysis obtained from (p-BthTX-I)2 are promising prototypes as novel drugs to treat multidrug-resistant bacterial infections.
Journal ArticleDOI
Pan-proteomics, a concept for unifying quantitative proteome measurements when comparing closely-related bacterial strains.
TL;DR: Pan-proteomics as discussed by the authors is an analytical concept that permits the ability to qualitatively and quantitatively compare the proteomes of genetically heterogeneous organisms, and it has been used extensively in the field of microbiology.
Journal ArticleDOI
Identification of surface proteins in a clinical Staphylococcus haemolyticus isolate by bacterial surface shaving.
Runa Wolden,Maria Pain,Roger Karlsson,Roger Karlsson,Anders Karlsson,Elizabeth G. Aarag Fredheim,Jorunn Pauline Cavanagh +6 more
TL;DR: This study has provided novel knowledge about expression of S. haemolyticus surface proteins after direct contact with eukaryotic cells and in media supplemented with serum and identified surface proteins and immune evasive proteins previously only functionally described in other staphylococcal species.
Journal ArticleDOI
Novel Cytoplasmic Bacteriocin Compounds Derived from Staphylococcus epidermidis Selectively Kill Staphylococcus aureus, Including Methicillin-Resistant Staphylococcus aureus (MRSA).
TL;DR: This work has extracted a novel thermolabile cytoplasmic bacteriocin from S. epidermidis using trichloroactic acid/acetone precipitation method after cell lysis with a SDS-containing buffer that selectively exhibited antimicrobial activity against S. aureus and MRSA.
Journal ArticleDOI
Proteomic Analysis Reveals a Biofilm-Like Behavior of Planktonic Aggregates of Staphylococcus epidermidis Grown Under Environmental Pressure/Stress
Marta Bottagisio,Alessio Soggiu,Cristian Piras,Alessandro Bidossi,Viviana Greco,Viviana Greco,Luisa Pieroni,Luigi Bonizzi,Paola Roncada,Arianna B. Lovati +9 more
TL;DR: Comparison of the whole proteomic profiles of two methicillin-resistant S. epidermidis strains growing in planktonic and in sessile form to investigate the molecular mechanisms underlying biofilm stability and provide preliminary results may inform comparative proteomic strategies in the study of mature bacterial biofilm.
References
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Journal ArticleDOI
Staphylococcus aureus infections.
TL;DR: In an elegant series of clinical observations and laboratory studies published in 1880 and 1882, Ogston described staphylococcal disease and its role in sepsis and abscess formation.
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STRING v9.1: protein-protein interaction networks, with increased coverage and integration
Andrea Franceschini,Damian Szklarczyk,Sune Frankild,Michael Kuhn,Milan Simonovic,Alexander Roth,Jianyi Lin,Pablo Minguez,Peer Bork,Christian von Mering,Lars Juhl Jensen +10 more
TL;DR: The update to version 9.1 of STRING is described, introducing several improvements, including extending the automated mining of scientific texts for interaction information, to now also include full-text articles, and providing users with statistical information on any functional enrichment observed in their networks.
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PSORTb 3.0
Nancy Yiu-Lin Yu,James R. Wagner,Matthew R. Laird,Gabor Melli,Sébastien Rey,Raymond Lo,Phuong Dao,S. Cenk Sahinalp,Martin Ester,Leonard J. Foster,Fiona S. L. Brinkman +10 more
TL;DR: This work developed PSORTb version 3.0 with improved recall, higher proteome-scale prediction coverage, and new refined localization subcategories, and evaluated the most accurate SCL predictors using 5-fold cross validation plus an independent proteomics analysis.
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CRISPR Interference Limits Horizontal Gene Transfer in Staphylococci by Targeting DNA
TL;DR: It is shown that CRISPR interference prevents conjugation and plasmid transformation in S. epidermidis and can limit the spread of antibiotic resistance in pathogenic bacteria.
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Staphylococcus epidermidis — the 'accidental' pathogen
TL;DR: The molecular basis of the commensal and infectious lifestyles of S. epidermidis is discussed, beginning to comprehend the roles in balancing the epithelial microflora and serving as a reservoir of resistance genes.