Journal ArticleDOI
Comparative toxicity of three halogenated dibenzofurans in guinea pigs, mice, and rhesus monkeys
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TLDR
The results reported in this manuscript extend earlier studies with TCDF in guinea pigs and mice, report the toxic effects in rhesus monkeys, and describe the Toxic effects of 2,3,4,7,8-pentachlorodibenzofuran (PCDF) and 2, 3,7&tetrabromodIBenzofurans (TBDF) in Guinea pigs.Abstract:
The chlorinated dibenzofurans have been reported to be present in a variety of polychlorinated biphenyls (PCBs)’” and in pentachlorophenol: They were also detected in the PCB-contaminated rice oil that was responsible for the human intoxication referred to as ‘Y~sho’.’.~ Polychlorinated dibenzofurans were also detected in tissues of patients with ‘Yusho’.’ A polychlorinated dibenzofuran fraction extracted from PCB’s was found to be highly toxic in chickens.* A mixture of polychlorinated dibenzofurans also caused toxic effects when fed to rats? 2,3,7,8Tetrachlorodibenzofuran (TCDF) has been evaluated for toxicity in chicks,” guinea pigs,” and mice.” The results reported in this manuscript extend earlier studies with TCDF in guinea pigs and mice, report the toxic effects in rhesus monkeys, and describe the toxic effects of 2,3,4,7,8-pentachlorodibenzofuran (PCDF) and 2,3,7&tetrabromodibenzofuran (TBDF) in guinea pigs.read more
Citations
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Journal ArticleDOI
Comparative Toxicology and Mechanism of Action of Polychlorinated Dibenzo-P-Dioxins and Dibenzofurans
Journal ArticleDOI
Developmental and Reproductive Toxicity of Dioxins and Related Compounds: Cross-Species Comparisons
TL;DR: Decreases in spermatogenesis and the ability to conceive and carry a pregnancy to term are the most sensitive signs of reproductive toxicity in male and female mammals, respectively.
Journal ArticleDOI
The toxicokinetics and metabolism of polychlorinated dibenzo-p-dioxins (PCDDs) and dibenzofurans (PCDFs) and their relevance for toxicity.
TL;DR: Human risk assessment for PCDDs and PCDFs needs to consider species-, congener-, and dose-specific toxicokinetic data, as exposure to complex mixtures, including PCBs, has the potential to alter the toxicokinetics of individual compounds.
Journal ArticleDOI
Health effects of polybrominated dibenzo-p-dioxins (PBDDs) and dibenzofurans (PBDFs)
TL;DR: The state of the science regarding the health effects of polybrominated dibenzo-p-dioxins (PBDDs) and dibenzofurans (PBDFs) is reviewed, suggesting that brominated compounds have similar toxicity profiles to their chlorinated homologs.
Health hazard evaluation report
TL;DR: A study was made of possible reasons for workers losing time from work at the Maritime Administration Reserve Fleets at Benicia, California and Fort Eustis, Virginia, and possible exposure to asbestos observed at both sites.
References
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Journal ArticleDOI
The comparative toxicity of chlorinated dibenzo-p-dioxins in mice and guinea pigs.
TL;DR: At the toxic dose the spectrum and severity of lesions and organ weight effects were similar for all homologs and isomers within the same animal species; however, there were interspecies differences.
Journal ArticleDOI
Identification and toxicological evaluation of chlorinated dibenzofuran and chlorinated naphthalene in two commercial polychlorinated biphenyls.
TL;DR: It is concluded that evaluation of animal tests on PCB is made extremely difficult by the presence of chlorinated dibenzofurans in some commercial PCB preparations.
Journal ArticleDOI
Pathologic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin in laboratory animals.
TL;DR: Images courtesy of AFP, EPA, Getty Images, Reuters and Reuters.
Journal ArticleDOI
Identification of chlorinated dibenzofurans in American polychlorinated biphenyls
TL;DR: P,p′-DDE, other chlorinated biocides and/or their derivatives, and the polychlorinated biphenyls are among the most toxic substances known and are possible causes of the observed mortality in bird populations which suffer embryonic mortality.
Journal ArticleDOI
Toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in rhesus monkeys (Macaca mulatta) following a single oral dose.
TL;DR: The oral LD50 of 2,3,7,8-tetrachlorodibenzo-p-dioxin in female rhesus monkeys was higher than the LD50 in rats following a single Oral Dose of dioxin.