Journal ArticleDOI
Comparative typing of human kidney cells and lymphocytes by immune adherence1
TLDR
The results support the concept that significant quantitative differences in the expression of isoantigens exist among different cell types.Abstract:
SUMMARY The immune adherence technique was modified to permit a direct comparison between the reactivity of lymphocytes and kidney cells from the same person. These two cells were typed using 17 well characterized antisera. There were 82 significant discrepancies from a total of 234 direct comparisons. Absorptions with the negatively reacting cell resulted in diminished or absent serological activity against the positive cell type. The results support the concept that significant quantitative differences in the expression of isoantigens exist among different cell types.read more
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Journal ArticleDOI
Antibodies and antigen expression in human melanoma detected by the immune adherence test.
Santoso Cornain,Jan E. de Vries,John G. Collard,Claudia Vennegoor,Ineke Van Wingerden,Philip Rümke +5 more
TL;DR: Sera from melanoma patients tested for the presence of antimelanoma antibodies indicated that conversions in antibody activity did not correlate with the clinical state of the patients, and no correlation with the corresponding in vitro data obtained in cell‐mediated immunity tests.
Journal ArticleDOI
Effect of cell surface antigen density on immunological enhancement.
TL;DR: The density of antigens on the surface of allograft target cells seems to determine whether IgG antibody manifests predominantly its cytotoxic action or whether immunologicol enhancement can operate.
Book ChapterDOI
Complement and tumor immunology.
TL;DR: This chapter provides an overview of the theoretical considerations and practical applications of complement research to tumor immunology in each of five projects—namely, the immunological cell receptors, (1) immune adherence, (3) C1 fixation and transfer test, (4) complement fixation test, and (5) immune cytotoxicity test.
Journal ArticleDOI
KIDNEY-SPECIFIC ALLOANTIGEN SYSTEM IN THE RAT Characterization and Role in Transplantation*
D. N. J. Hart,John W. Fabre +1 more
TL;DR: Species cross- reactivity studies showed that rabbit, dog, and human kidneys could absorb this specificity, although more weakly than DA kidney, and that only the DA MHC was involved in primary graft rejection of DA kidneys by LEW rats.