Comparison of Hemoglobin A1c with Fasting and 2-h Plasma Glucose Tests for Diagnosis of Diabetes and Prediabetes among High-risk South Indians.
Pedapati Radhakrishna,Kolar Vishwanath Vinod,Akkilagunta Sujiv,Rathinam Palamalai Swaminathan +3 more
TLDR
HbA1c ≥6.5% is a convenient and reliable alternative to plasma glucose tests to diagnose diabetes among high-risk South Indians and 0.6% had 100% negative predictive value to exclude prediabetes/diabetes.Abstract:
Background: Glycosylated hemoglobin (HbA1c) has not been evaluated extensively for diabetes and prediabetes diagnosis and short-term variability of fasting plasma glucose (FPG), 2-h PG post-75 g glucose load (2 hPG) and HbA1c has not been studied among Indians. Objectives: The study aimed to compare the sensitivity of HbA1c, FPG and 2 hPG for diabetes and prediabetes diagnosis as per the American Diabetes Association criteria, assess short-term variability of three tests and determine optimal HbA1c cutoffs for diabetes and prediabetes diagnosis among high-risk south Indians. Methods: This diagnostic accuracy study, conducted at a tertiary care teaching hospital located in South India, enrolled 332 adults at high risk for diabetes and subjected them to testing (FPG, 2 hPG, and HbA1c) twice at 2–3 weeks interval. Sensitivity of three tests for diagnosing diabetes and prediabetes was determined based on the final diagnosis of normoglycemia/prediabetes/diabetes made with six test results for each participant. Optimal HbA1c cutoffs for diabetes and prediabetes were determined based on the final diagnosis of glycemic status made with four test results of FPG and 2 hPG. Results: FPG, 2 hPG, and HbA1c, at American Diabetes Association recommended values, had sensitivity of 84.4%, 97%, and 93.8% respectively for diabetes diagnosis. HbA1c had lowest short-term variability (CVw = 1.6%). Receiver operating characteristic curve plotted with mean (of two values) HbA1c for each participant showed optimal HbA1c cutoffs of 6.5% for diabetes (area under curve [AUC] =0.990, sensitivity = 95.8%, specificity = 96.2%, accuracy = 95.2%) and 5.9% for prediabetes (AUC = 0.893, sensitivity = 84.3%, specificity = 80%, accuracy = 75.6%) diagnosis respectively. HbA1cread more
Citations
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RSSDI-ESI Clinical Practice Recommendations for the Management of Type 2 Diabetes Mellitus 2020.
TL;DR: The present paper presents a meta-analysis of 148 cases of type 2 diabetes patients treated at the UCMS-GTB Hospital in Ahmedabad over a 12-month period from May 2013 to March 2014 that showed clear trends in disease progression and in particular in cases of high blood pressure and insulin resistance.
Journal ArticleDOI
RSSDI-ESI Clinical Practice Recommendations for the Management of Type 2 Diabetes Mellitus 2020
TL;DR: The present paper presents a meta-analysis of 148 cases of type 2 diabetes patients treated at the UCMS-GTB Hospital in Ahmedabad over a 12-month period from May 2013 to March 2014 that showed clear trends in disease progression and in particular in cases of high blood pressure and insulin resistance.
Journal ArticleDOI
Management of periodontal disease in patients with diabetes- good clinical practice guidelines: A joint statement by Indian Society of Periodontology and Research Society for the Study of Diabetes in India
Ashish Jain,Manoj Chawla,Ashish Kumar,Rajeev Chawla,Vishakha Grover,Sujoy Ghosh,Nymphea Pandit,Purvi M. Chawla +7 more
TL;DR: This paper describes a joint statement put forth by the Indian Society of Periodontology and the Research Society for the Study of Diabetes in India aiming to provide expert consensus and evidence-based guidelines for optimal clinical management of periodontal conditions in diabetes patients or patients at risk for diabetes.
Journal ArticleDOI
Glycated hemoglobin (HbA1c) as diagnostic criteria for diabetes: the optimal cut-off points values for the Pakistani population; a study from second National Diabetes Survey of Pakistan (NDSP) 2016-2017.
Abdul Basit,Asher Fawwad,Khalid Abdul Basit,Nazish Waris,Bilal Tahir,Iftikhar Ahmed Siddiqui +5 more
TL;DR: Findings from second NDSP demonstrated disagreement between findings of OGTT and HbA1c as diagnostic tool for Pakistani population, which might require ethnic or regional-based modification in cut-off points.
Journal ArticleDOI
Burden of Type 2 Diabetes and Associated Cardiometabolic Traits and Their Heritability Estimates in Endogamous Ethnic Groups of India: Findings From the INDIGENIUS Consortium
Vettriselvi Venkatesan,Juan Carlos López-Alvarenga,Rector Arya,Deepika Ramu,Teena Koshy,Umarani Ravichandran,Amaresh Reddy Ponnala,Surendra K. Sharma,Sailesh Lodha,Krishna K. Sharma,Mahaboob V. Shaik,Roy G. Resendez,Priyanka Goel Venugopal,Noelta Saju,Juliet Amuche Ezeilo,Cynthia Bejar,Gurpreet Singh Wander,Sarju Ralhan,Jai Rup Singh,Narinder K. Mehra,Raghavendra Rao Vadlamudi,Marcio Almeida,Srinivas Mummidi,Chidambaram Natesan,John Blangero,Krishna Mohan Medicherla,S. Thanikachalam,Thyagarajan S. Panchatcharam,Dileep Kumar Kandregula,Rajeev Gupta,Dharambir K. Sanghera,Ravindranath Duggirala,Solomon F. D. Paul +32 more
TL;DR: The heritability estimates of T2D in the CH, RE, SI, and AG EEGs were found to be 30%, 46%, 54%, and 82% respectively, and statistically significant (P ≤ 0.05).
References
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Prevalence of diabetes in Asian Indians based on glycated hemoglobin and fasting and 2-H post-load (75-g) plasma glucose (CURES-120).
Adamsha Nazir,Rozario Papita,Viknesh Prabu Anbalagan,Ranjit Mohan Anjana,Mohan Deepa,Viswanathan Mohan +5 more
TL;DR: In Asian Indians, use of A1c criteria would result in markedly higher prevalence rates of diabetes and identifies a different set of individuals with milder glucose intolerance and lower serum triglyceride levels.
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HbA1c and the diagnosis of diabetes and prediabetes in a middle-aged and elderly Han population from northwest China (HbA1c).
Shengli Wu,Fengshou Yi,Chao Zhou,Mintao Zhang,Yujing Zhu,Yilihamu Tuniyazi,Lijuan Huang,Xuefang Huang,Fugang Wang,Yufang Bi,Guang Ning +10 more
TL;DR: In this paper, the optimal threshold of HbA1c was identified for diagnosing diabetes and prediabetes in a middle-aged and elderly Han Chinese population from northwest China.
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Prevalence of type 2 diabetes among high-risk adults in Shanghai from 2002 to 2012
Congrong Wang,Yinan Zhang,Lei Zhang,Xuhong Hou,Huijuan Lu,Yixie Shen,Ruihua Chen,Pingyan Fang,Hong Yu,Ming Li,Feng Zhang,Haibing Chen,Haoyong Yu,Jian Zhou,Fang Liu,Yuqian Bao,Weiping Jia +16 more
TL;DR: Sex, age, parental diabetic history, and being overweight were associated with an increased risk for diabetes in high-risk people in Shanghai, and screening programs targeting these individuals may be beneficial.
Journal ArticleDOI
Accuracy of glycated haemoglobin in screening for pre‐diabetes in Asian Indians—a community survey: the Chandigarh Urban Diabetes Study (CUDS)
TL;DR: To compare American Diabetes Association and International Expert Committee recommended cut‐off values of HbA1c for detecting the presence of pre‐diabetes against plasma glucose values obtained from oral glucose tolerance tests in Asian Indians.
Journal ArticleDOI
Total Short-term Variability in Biomarkers of Hyperglycemia in Older Adults
Christina M. Parrinello,Pamela L. Lutsey,David Couper,John H. Eckfeldt,Michael W. Steffes,Josef Coresh,Elizabeth Selvin +6 more
TL;DR: The 6-week total variability in fructosamine, glycated albumin, and 1,5-AG in older adults with and without diabetes is quantified and compared to that of fasting glucose and Hb A1c.