N
Narinder K. Mehra
Researcher at All India Institute of Medical Sciences
Publications - 215
Citations - 8436
Narinder K. Mehra is an academic researcher from All India Institute of Medical Sciences. The author has contributed to research in topics: Human leukocyte antigen & Population. The author has an hindex of 42, co-authored 211 publications receiving 7383 citations.
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Journal ArticleDOI
A comprehensive 1000 Genomes–based genome-wide association meta-analysis of coronary artery disease
Majid Nikpay,Anuj Goel,Won H-H.,Leanne M. Hall,Christina Willenborg,Stavroula Kanoni,Danish Saleheen,Theodosios Kyriakou,Christopher P. Nelson,Christopher P. Nelson,Jemma C. Hopewell,Tom R. Webb,Tom R. Webb,Lingyao Zeng,Abbas Dehghan,Maris Alver,Sebastian M. Armasu,Kirsi Auro,Kirsi Auro,Andrew Bjonnes,Daniel I. Chasman,Shufeng Chen,Ian Ford,Nora Franceschini,Christian Gieger,Christopher Grace,Stefan Gustafsson,Jie Huang,Hwang S-J.,Yun Kyoung Kim,Marcus E. Kleber,King Wai Lau,Xiangfeng Lu,Yingchang Lu,Lyytikäinen L-P.,Evelin Mihailov,Alanna C. Morrison,Natalia Pervjakova,Natalia Pervjakova,Natalia Pervjakova,Liming Qu,Lynda M. Rose,Elias Salfati,Richa Saxena,Markus Scholz,Albert V. Smith,Emmi Tikkanen,André G. Uitterlinden,Xueli Yang,Weihua Zhang,Wei Zhao,M. De Andrade,P. De Vries,N. R. van Zuydam,N. R. van Zuydam,Sonia S. Anand,Lars Bertram,Frank Beutner,George Dedoussis,Philippe M. Frossard,Dominique Gauguier,Alison H. Goodall,Omri Gottesman,Marc Haber,Han B-G.,Shapour Jalilzadeh,Thorsten Kessler,Inke R. König,Lars Lannfelt,Wolfgang Lieb,Lars Lind,Cecilia M. Lindgren,Lokki M-L.,Lokki M-L.,Patrik K. E. Magnusson,Nadeem Hayyat Mallick,Narinder K. Mehra,Thomas Meitinger,Memon F-U-R.,Andrew P. Morris,Andrew P. Morris,Markku S. Nieminen,Nancy L. Pedersen,Annette Peters,Loukianos S. Rallidis,Adil Rasheed,M Samuel,Svati H. Shah,Juha Sinisalo,Kathleen Stirrups,Stella Trompet,Ligui Wang,Ligui Wang,Khan Shah Zaman,Diego Ardissino,Eric Boerwinkle,Ingrid B. Borecki,Erwin P. Bottinger,Julie E. Buring,John C. Chambers,Rory Collins,L. A. Cupples,L. A. Cupples,John Danesh,Ilja Demuth,Roberto Elosua,Stephen E. Epstein,Tõnu Esko,Mary F. Feitosa,Oscar H. Franco,MariaGrazia Franzosi,Christopher B. Granger,Dongfeng Gu,Vilmundur Gudnason,Alistair S. Hall,Anders Hamsten,Tamara B. Harris,Stanley L. Hazen,Christian Hengstenberg,Albert Hofman,Erik Ingelsson,Carlos Iribarren,J W Jukema,Pekka J. Karhunen,Kim B-J.,Jaspal S. Kooner,Iftikhar J. Kullo,Terho Lehtimäki,Loos Rjf.,Olle Melander,Andres Metspalu,Winfried März,Winfried März,Winfried März,Colin N. A. Palmer,Markus Perola,Markus Perola,Markus Perola,Thomas Quertermous,Daniel J. Rader,Paul M. Ridker,Samuli Ripatti,Samuli Ripatti,Robert Roberts,Veikko Salomaa,Dharambir K. Sanghera,Stephen M. Schwartz,Udo Seedorf,Alexandre F.R. Stewart,David J. Stott,Joachim Thiery,Pierre Zalloua,Christopher J. O'Donnell,Christopher J. O'Donnell,Muredach P. Reilly,Themistocles L. Assimes,John R. Thompson,Jeanette Erdmann,Robert Clarke,Hugh Watkins,Sekar Kathiresan,Ruth McPherson,Panos Deloukas,Panos Deloukas,Heribert Schunkert,Nilesh J. Samani,Nilesh J. Samani,Martin Farrall +167 more
TL;DR: This article conducted a meta-analysis of coronary artery disease (CAD) cases and controls, interrogating 6.7 million common (minor allele frequency (MAF) > 0.05) and 2.7 millions low-frequency (0.005 < MAF < 0.5) variants.
A comprehensive 1000 Genomes-based genome-wide association meta-analysis of coronary artery disease
Majid Nikpay,Anuj Goel,Hong-Hee Won,Leanne M. Hall,Christina Willenborg,Stavroula Kanoni,Danish Saleheen,Theodosios Kyriakou,Christopher P. Nelson,Jemma C. Hopewell,Tom R. Webb,Lingyao Zeng,Abbas Dehghan,Maris Alver,Sebastian M. Armasu,Kirsi Auro,Andrew Bjonnes,Daniel I. Chasman,Shufeng Chen,Ian Ford,Nora Franceschini,Christian Gieger,Christopher Grace,Stefan Gustafsson,Jie Huang,Shih-Jen Hwang,Yun Kyoung Kim,Marcus E. Kleber,King Wai Lau,Xiangfeng Lu,Yingchang Lu,Leo-Pekka Lyytikäinen,Evelin Mihailov,Alanna C. Morrison,Natalia Pervjakova,Liming Qu,Lynda M. Rose,Elias Salfati,Richa Saxena,Markus Scholz,Albert V. Smith,Emmi Tikkanen,André G. Uitterlinden,Xueli Yang,Weihua Zhang,Wei Zhao,Mariza de Andrade,Paul S. de Vries,Natalie R. van Zuydam,Sonia S. Anand,Lars Bertram,Frank Beutner,George Dedoussis,Philippe M. Frossard,Dominique Gauguier,Alison H. Goodall,Omri Gottesman,Marc Haber,Bok-Ghee Han,Jianfeng Huang,Shapour Jalilzadeh,Thorsten Kessler,Inke R. Koenig,Lars Lannfelt,Wolfgang Lieb,Lars Lind,Cecilia M. Lindgren,Marja-Liisa Lokki,Patrik K. E. Magnusson,Nadeem Hayat Mallick,Narinder K. Mehra,Thomas Meitinger,Fazal-ur-Rehman Memon,Andrew P. Morris,Markku S. Nieminen,Nancy L. Pedersen,Annette Peters,Loukianos S. Rallidis,Asif Rasheed,Maria Samuel,Svati H. Shah,Juha Sinisalo,Kathleen Stirrups,Stella Trompet,Laiyuan Wang,Khan Shah Zaman,Diego Ardissino,Eric Boerwinkle,Ingrid B. Borecki,Erwin P. Bottinger,Julie E. Buring,John C. Chambers,Rory Collins,L. Adrienne Cupples,John Danesh,Ilja Demuth,Roberto Elosua,Stephen E. Epstein,Tõnu Esko,Mary F. Feitosa,Oscar H. Franco,Maria Grazia Franzosi,Christopher B. Granger,Dongfeng Gu,Vilmundur Gudnason,Alistair S. Hall,Anders Hamsten,Tamara B. Harris,Stanley L. Hazen,Christian Hengstenberg,Albert Hofman,Erik Ingelsson,Carlos Iribarren,J. Wouter Jukema,Pekka J. Karhunen,Bong-Jo Kim,Jaspal S. Kooner,Iftikhar J. Kullo,Terho Lehtimäki,Ruth J. F. Loos,Olle Melander,Andres Metspalu,Winfried Maerz,Colin N. A. Palmer,Markus Perola,Thomas Quertermous,Daniel J. Rader,Paul M. Ridker,Samuli Ripatti,Robert Roberts,Veikko Salomaa,Dharambir K. Sanghera,Stephen M. Schwartz,Udo Seedorf,Alexandre F.R. Stewart,David J. Stott,Joachim Thiery,Pierre Zalloua,Christopher J. O'Donnell,Muredach P. Reilly,Themistocles L. Assimes,John R. Thompson,Jeanette Erdmann,Robert Clarke,Hugh Watkins,Sekar Kathiresan,Ruth McPherson,Panos Deloukas,Heribert Schunkert,Nilesh J. Samani,Martin Farrall +150 more
TL;DR: A GWAS meta-analysis of CAD cases and controls provides a comprehensive survey of the fine genetic architecture of CAD, showing that genetic susceptibility to this common disease is largely determined by common SNPs of small effect size.
Journal ArticleDOI
Impact of nine common type 2 diabetes risk polymorphisms in Asian Indian Sikhs: PPARG2 (Pro12Ala), IGF2BP2, TCF7L2 and FTO variants confer a significant risk.
Dharambir K. Sanghera,Lyda Ortega,Shizhong Han,Jai Rup Singh,Sarju Ralhan,Gurpreet Singh Wander,Narinder K. Mehra,John J. Mulvihill,Robert E. Ferrell,Swapan K. Nath,Kamboh Mi +10 more
TL;DR: This is first study reporting the role of some recently emerged loci with T2D in a high risk population of Asian Indian origin and the impact of these variants on body mass index, waist to hip ratio, fasting insulin, and glucose and lipid levels using multiple linear regression analysis.
Journal ArticleDOI
HLA-B27 subtypes in Asian patients with ankylosing spondylitis Evidence for new associations
Carlos López-Larrea,K. Sujirachato,Narinder K. Mehra,P. Chiewsilp,D. Isarangkura,Uma Kanga,O. Dominguez,Eliecer Coto,M. Penã,Fernando Setien,S. Gonzalez-Roces +10 more
TL;DR: The polymerase chain reaction (PCR) in combination with the sequence-specific oligonucleotide probes (SSOs) was used to analyse the polymorphism in exon 2 and 3 of HLA-B27 in two Asian groups with different genetic HLA structures: Indian and Thai populations.
Journal ArticleDOI
Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease
Wei Zhao,Asif Rasheed,Emmi Tikkanen,Jung-Jin Lee,Adam S. Butterworth,Joanna M. M. Howson,Themistocles L. Assimes,Rajiv Chowdhury,Marju Orho-Melander,Scott M. Damrauer,Aeron Small,Senay Asma,Minako Imamura,Toshimasa Yamauch,John C. Chambers,Peng Chen,Bishwa Raj Sapkota,Nabi Shah,Sehrish Jabeen,Praveen Surendran,Yingchang Lu,Weihua Zhang,Atif Imran,Shahid Abbas,Faisal Majeed,Kevin Trindade,Nadeem Qamar,Nadeem Hayyat Mallick,Zia Yaqoob,Tahir Saghir,Syed Nadeem Hasan Rizvi,Anis Memon,Syed Zahed Rasheed,Fazal-ur-Rehman Memon,Khalid Mehmood,Naveeduddin Ahmed,Irshad Hussain Qureshi,Tanveer-us-Salam,Wasim Iqbal,Uzma Malik,Narinder K. Mehra,Jane Z. Kuo,Wayne H-H Sheu,Xiuqing Guo,Chao A. Hsiung,Jyh-Ming Jimmy Juang,Kent D. Taylor,Yi-Jen Hung,Wen-Jane Lee,Thomas Quertermous,I-Te Lee,Chih-Cheng Hsu,Erwin P. Bottinger,Sarju Ralhan,Yik Ying Teo,Tzung-Dau Wang,Dewan S. Alam,Emanuele Di Angelantonio,Steve Epstein,Sune F. Nielsen,Børge G. Nordestgaard,Anne Tybjærg-Hansen,Robin Young,M. Benn,Ruth Frikke-Schmidt,Pia R. Kamstrup,Michigan Biobank,J. Wouter Jukema,Naveed Sattar,Roelof A.J. Smit,Ren-Hua Chung,Kae-Woei Liang,Sonia S. Anand,Dharambir K. Sanghera,Samuli Ripatti,Ruth J. F. Loos,Jaspal S. Kooner,E. Shyong Tai,Jerome I. Rotter,Yii-Der Ida Chen,Philippe M. Frossard,Shiro Maeda,Takashi Kadowaki,Muredach P. Reilly,Guillaume Paré,Olle Melander,Veikko Salomaa,Daniel J. Rader,John Danesh,Benjamin F. Voight,Danish Saleheen +90 more
TL;DR: A genome-wide, multi-ancestry study of genetic variation for type 2 diabetes and coronary heart disease finds variants associated with both outcomes implicate new pathways as well as targets of existing drugs, including icosapent ethyl and adipocyte fatty-acid-binding protein.