L
Lei Zhang
Researcher at Shanghai Jiao Tong University
Publications - 101
Citations - 3243
Lei Zhang is an academic researcher from Shanghai Jiao Tong University. The author has contributed to research in topics: Type 2 diabetes & Diabetes mellitus. The author has an hindex of 24, co-authored 92 publications receiving 2371 citations. Previous affiliations of Lei Zhang include Salk Institute for Biological Studies & Foundation University, Islamabad.
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Journal ArticleDOI
In vivo direct reprogramming of reactive glial cells into functional neurons after brain injury and in an Alzheimer's disease model.
TL;DR: It is shown that reactive glial cells in the cortex of stab-injured or Alzheimer's disease model mice can be directly reprogrammed into functional neurons in vivo using retroviral expression of a single neural transcription factor, NeuroD1.
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Association of Time in Range, as Assessed by Continuous Glucose Monitoring, With Diabetic Retinopathy in Type 2 Diabetes
Jingyi Lu,Xiaojing Ma,Jian Zhou,Lei Zhang,Yifei Mo,Lingwen Ying,Wei Lu,Wei Zhu,Yuqian Bao,Robert A. Vigersky,Weiping Jia +10 more
TL;DR: TIR assessed by CGM is associated with DR in type 2 diabetes, and adjustment of GV metrics partially attenuated these associations, although the link between TIR and the presence of any DR remained significant.
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Small Molecules Efficiently Reprogram Human Astroglial Cells into Functional Neurons
Lei Zhang,Jiu Chao Yin,Hana Yeh,Ning Xin Ma,Grace Lee,Xiangyun Amy Chen,Yanming Wang,Li Lin,Li Chen,Peng Jin,Gang Yi Wu,Gang Yi Wu,Gong Chen +12 more
TL;DR: This study reports that a combination of small molecules can also reprogram human astrocytes in culture into fully functional neurons, opening a new avenue using chemical compounds to reprogram reactive glial cells into functional neurons.
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KCC2 rescues functional deficits in human neurons derived from patients with Rett syndrome
Xin Tang,Julie Kim,Li Zhou,Eric Wengert,Lei Zhang,Zheng Wu,Cassiano Carromeu,Alysson R. Muotri,Maria C. Marchetto,Fred H. Gage,Gong Chen +10 more
TL;DR: It is demonstrated that neuron-specific K+-Cl− cotransporter2 (KCC2) is a critical downstream gene target of MeCP2, and that RE1-silencing transcriptional factor, REST, a neuronal gene repressor, mediates the Me CP2 regulation of KCC2.
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Protective effect of resveratrol against kainate-induced temporal lobe epilepsy in rats.
TL;DR: Results suggest that Res is a potent anti-epilepsy agent, which protects against epileptogenesis and progression of the kainate-induced TLE animal.