Journal ArticleDOI
Comparison of novel hemostatic dressings with QuikClot combat gauze in a standardized swine model of uncontrolled hemorrhage.
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TLDR
The results suggest that the novel hemostatic devices perform at least as well as the current Committee on Tactical Combat Casualty Care standard for point-of-injury hemorrhage control.Abstract:
BACKGROUNDUncontrolled hemorrhage is the leading cause of preventable death on the battlefield. The development, testing, and application of novel hemostatic dressings may lead to a reduction of prehospital mortality through enhanced point-of-injury hemostatic control. This study aimed to determineread more
Citations
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Journal ArticleDOI
Biomaterials and Advanced Technologies for Hemostatic Management of Bleeding.
TL;DR: A comprehensive review regarding the various topical, intracavitary, and intravenous hemostatic technologies in terms of materials, mechanisms, and state‐of‐art is provided, and challenges and opportunities to help advancement of the field are discussed.
Journal ArticleDOI
Ten-Year Analysis of Transfusion in Operation Iraqi Freedom and Operation Enduring Freedom: Increased Plasma and Platelet Use Correlates with Improved Survival
Heather F. Pidcoke,James K. Aden,Alejandra G. Mora,Matthew A. Borgman,Philip C. Spinella,Michael A. Dubick,Lorne H. Blackbourne,Andrew P. Cap +7 more
TL;DR: A 10-year evaluation of the Joint Theater Trauma Registry database reports the military’s experience with resuscitation and coagulopathy, evaluates the effect of increased plasma and platelet (PLT)–to-red blood cell ratios, and analyzes other recent changes in practice.
Journal ArticleDOI
A review on recent advances in chitosan based composite for hemostatic dressings.
TL;DR: This review provides performance analysis of chitosan bandage generations and discusses the progress made in its fabrication methods during the recent years.
Journal ArticleDOI
Review of New Topical Hemostatic Dressings for Combat Casualty Care
TL;DR: Evaluation of third-generation hemostatic dressings reveals that mucoadhesive (chitosan) dressings, particularly Celox Gauze and ChitoGauze, clearly show equal efficacy to Combat Gauze across many dependent variables.
Journal ArticleDOI
Inorganic hemostats: The state-of-the-art and recent advances.
Sara Pourshahrestani,Ehsan Zeimaran,Ivan Djordjevic,Nahrizul Adib Kadri,Mark R. Towler,Mark R. Towler +5 more
TL;DR: The most commonly used inorganic hemostats, subcategorized as zeolite and clay-based hemostat, are reviewed, and their hemostatic functions as well as their structural properties that are believed to induce hemostasis are discussed.
References
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Journal ArticleDOI
Guide for the Care and Use of Laboratory Animals
TL;DR: The Guide for the Care and Use of Laboratory Animals by the Institute for Laboratory Animal Research (ILAR) of the National Research Council in the USA, is well known among most individuals involved in laboratory animal care and use and the overall intention is to support the readers to build a programme which creates a system of selfregulation and regulatory oversight.
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Combat wounds in operation Iraqi Freedom and operation Enduring Freedom
Brett D. Owens,John F Kragh,Joseph C. Wenke,Joseph M Macaitis,Charles E. Wade,John B. Holcomb +5 more
TL;DR: The wounding patterns currently seen in Iraq and Afghanistan resemble the patterns from previous conflicts, with some notable exceptions: a greater proportion of head and neck wounds, and a lower proportion of thoracic wounds.
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Injury severity and causes of death from Operation Iraqi Freedom and Operation Enduring Freedom: 2003-2004 versus 2006.
Joseph F. Kelly,Amber E. Ritenour,Daniel F. McLaughlin,Karen A. Bagg,Amy Apodaca,Craig T. Mallak,Lisa Pearse,Mary M. Lawnick,Howard R. Champion,Charles E. Wade,John B. Holcomb +10 more
TL;DR: Autopsies of the earliest combat deaths from Iraq and Afghanistan and the latest deaths of 2006 were analyzed to assess changes in injury severity and causes of death, finding that the severity of wounds has increased over time.
Journal ArticleDOI
Determination of efficacy of new hemostatic dressings in a model of extremity arterial hemorrhage in swine.
TL;DR: CG was the most effective dressing tested in this arterial hemorrhage model and is now recommended as the first line of treatment for life-threatening hemorrhage on the battlefield, replacing HC.
Journal ArticleDOI
Safety evaluation of new hemostatic agents, smectite granules, and kaolin-coated gauze in a vascular injury wound model in swine.
Bijan S. Kheirabadi,James E. Mace,Irasema B Terrazas,Chriselda G. Fedyk,J S Estep,Michael A. Dubick,Lorne H. Blackbourne +6 more
TL;DR: Investigation of the thromboembolic risk of using WoundStat granules when compared with kaolin-coated gauze, Combat Gauze (CG); or regular gauzes, Kerlix (KX) to treat an external wound with vascular injuries in pigs found significant endothelial injury and significant transmural damage to the vessels that render them nonviable for primary surgical repair.