Comparison of zinc concentrations in blood and seminal plasma and the various sperm parameters between fertile and infertile men.
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On the basis of the findings of this study and those of other reports, zinc may contribute to fertility through its positive effect on spermatogenesis.Abstract:
The aim of the study was to examine the relationships between concentrations of zinc in blood and seminal plasma and sperm quality among infertile and fertile men. One hundred seven male (infertile group) partners of couples who were undergoing investigation for infertility with no known cause for the infertility and 103 men (fertile group) whose wives were pregnant at the time of the study were recruited. The subjects' blood and seminal plasma concentration of zinc were determined by atomic absorption spectroscopy. Except for semen volume, all the other semen parameters for the infertile men were significantly lower than those for the fertile group. The geometric means of the seminal plasma zinc concentration were significantly lower in the infertile group compared with those in the fertile group; 183.6 mg/L (range, 63-499) versus 274.6 mg/L (range, 55-420). There were no significant differences in the geometric means of the blood zinc concentration between the 2 groups. Seminal plasma zinc concentration was significantly correlated with sperm density (r = 0.341, P < .0001), motility (r = 0.253, P < .0001), and viability (r = 0.286, P < .0001). On the basis of the findings of this study and those of other reports, zinc may contribute to fertility through its positive effect on spermatogenesis.read more
Citations
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The Effects of Metals as Endocrine Disruptors
TL;DR: This review reports current knowledge regarding the roles that cadmium (Cd), mercury (Hg), arsenic (As), lead (PB), manganese (Mn), and zinc (Zn) play as endocrine-disrupting chemicals (EDCs).
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Effects of folic acid and zinc sulfate on male factor subfertility: a double-blind, randomized, placebo-controlled trial.
Wai Yee Wong,Hans M.W.M. Merkus,Chris M.G. Thomas,Roelof Menkveld,Gerhard A. Zielhuis,Régine P.M. Steegers-Theunissen +5 more
TL;DR: Total normal sperm count increases after combined zinc sulfate and folic acid treatment in both subfertile and fertile men, and this finding opens avenues of future fertility research and treatment and may affect public health.
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Sperm DNA damage caused by oxidative stress: modifiable clinical, lifestyle and nutritional factors in male infertility.
TL;DR: DNA fragmentation is an important factor in the aetiology of male infertility, however it is still underevaluated and its inclusion in routine semen analysis is debated, and sources of oxidative stress should be thoroughly examined in men with high levels of DNA fragmentation and modified where possible.
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Antioxidant intake is associated with semen quality in healthy men
TL;DR: In a convenience sample of healthy non-smoking men from a non-clinical setting, higher antioxidant intake was associated with higher sperm numbers and motility.
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Zinc levels in seminal plasma are associated with sperm quality in fertile and infertile men
TL;DR: Poor Zn nutrition may be an important risk factor for low quality of sperm and idiopathic male infertility.
References
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Zinc, copper and selenium in reproduction
R. S. Bedwal,A. Bahuguna +1 more
TL;DR: Of the nine biological trace elements, zinc, copper and selenium are important in reproduction in males and females and the level of testosterone in the male has been suggested to play a role in the severity of copper deficiency.
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Reactive oxygen species released by activated neutrophils, but not by deficient spermatozoa, are sufficient to affect normal sperm motility.
TL;DR: The production of ROS by deficient spermatozoa is low and of no consequence to the motility of normal spermatozosa present in the same sperm preparation, however, 1 x 10(6) activated PMN/mL, with a 1,000-fold higher ROS production, have detrimental effects on the motilty of normal washed spermarozoa.
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Glutathione as a treatment for male infertility
TL;DR: Glutathione administered in vivo to patients who may have infertility secondary to excessive oxidative stress appears to act at the epididymis and during spermatogenesis, to improve the function of ejaculated spermatozoa.