Concentration of ciprofloxacin in human serum, lung and pleural tissues and fluids during and after lung surgery.

TLDR: A similar study with repeated doses extending over 24 h, also including measurements of ciprofloxacin in pleural tissue and exudate is made, in contrast to the study by Schlenkhoff et al, which was measured by an HPLC method.

Abstract: Data recently published in this journal by Schlenkhoff et al. (1) give evidence for a marked penetration of ciprofloxacin into human lung tissue, but these authors measured ciprofloxacin only over a period of 4 h. We therefore have made a similar study with repeated doses extending over 24 h, also including measurements of ciprofloxacin in pleural tissue and exudate. In contrast to the study by Schlenkhoff et al., ciprofloxacin was measured by an HPLC method. Sixteen patients undergoing lung surgery mainly because of cancer participated in the study after they had given their written informed consent. The age of the patients ranged between 47 and 76 years (mean 52 + 15 years), their bodyweight ranged from 47 to 92 kg (average 66.0 + 12.2 kg). They received three i.v. infusions of 200 mg ciprofloxacin at 12 h intervals, each infusion lasting 30 min. Surgical procedures started 1 h (nine patients) or 2 h (seven patients) after the first application of ciprofloxacin. Samples of serum, tissues and pleural exudate were obtained at the following time points: serum 1 or 2 h after the beginning of the first and just prior to the second and third infusions; lung and pleurat tissue during the course of surgery 1 and 2 h after the first infusion; pleural