Journal ArticleDOI
Concise and practical approach to chiral des-A B-trienic corticosteroids
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TLDR
In this article, a concise and practical route to the enantiomerically pure des-A B-trienic steroid was developed by thermolysis of the optically active alkenic benzocyclobutene 13 obtained by selective nucleophilic addition of isopropenyl group to the chiral epoxide 9 as a key step.Abstract:
A concise and practical route to the enantiomerically pure des-A B-trienic steroid 14 was developed by thermolysis of the optically active alkenic benzocyclobutene 13 obtained by selective nucleophilic addition of isopropenyl group to the chiral epoxide 9 as a key step.read more
Citations
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Recent chemistry of benzocyclobutenes
TL;DR: In this article, a review of aspects related to the synthesis, reactions and applications of benzocyclobutenes is presented, including reactions, reactions, and applications, as well as the synthesis process.
Journal ArticleDOI
Enantioselective synthesis of steroids
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Cycloadditions of ortho-quinodimethanes derived from benzocyclobutenes in organic synthesis. a review
TL;DR: In this paper, the authors describe the CYCLOADDITIONS OF ortho-quinodimETHANES DERIVED FROM BENZOCYCLOBUTENES in ORGANIC SYNTHESIS.
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Ring C closure as key step in the synthesis of steriods
TL;DR: In this paper, the authors reviewed the use of Torgov syntheses, Michael additions and cyclisations, aldol cyclisation, polyene cyclisations and Friedel-Crafts cyclisations for the construction of Ring C.
References
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Journal ArticleDOI
Horner-wadsworth-emmons reaction: Use of lithium chloride and an amine for base-sensitive compounds
Mary A. Blanchette,William Choy,Jeffery T. Davis,Amy P. Essenfeld,Satoru Masamune,William R. Roush,Toshiya Sakai +6 more
TL;DR: A mild olefination procedure, utilizing LiCl and an amine, has been developed for use with base-sensitive aldehydes and phosphonates as discussed by the authors.
Journal ArticleDOI
The synthetic methodology of nonracemic glycidol and related 2,3-epoxy alcohols
TL;DR: Berch et al. as mentioned in this paper presented a Synthetic Methodology of Nonra cemic Glycidol and Related 2,3-Epoxy Alcohols, Chemi cal Reviews, vol. 91, No. 4, (Jun. 1991) pp. 437-475.
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Regio- and stereoselective ring opening of epoxy alcohols with organoaluminium compounds leading to 1,2-diols
TL;DR: In this paper, the introduction of alkyl, alkynyl group, or hydride occurs regioselectively at the 3 position of the epoxy alcohols with inversion of the configuration upon treatment with organoaluminium reagents to produce vic-diols.