Journal ArticleDOI
Conversion of aliphatic amides into amines with [I,I-bis(trifluoroacetoxy)iodo]benzene. 1. Scope of the reaction
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This article is published in Journal of Organic Chemistry.The article was published on 1984-11-01. It has received 157 citations till now. The article focuses on the topics: (Bis(trifluoroacetoxy)iodo)benzene.read more
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A novel coumarin-labelled peptide for sensitive continuous assays of the matrix metalloproteinases.
TL;DR: In assays of the human matrix metalloproteinases, Mca‐Pro‐ Leu‐Gly‐Leu‐Dpa‐Ala‐Arg‐NH2 is about 50 to 100 times more sensitive than dinitrophenyl‐Pro •Leu •Gly •LeU‐Trp •Ala •d‐Arg •NH2 and continuous assays can be made at enzyme concentrations comparable to those used with macromolecular substrates.
Journal ArticleDOI
Hypervalent iodine reagents in the total synthesis of natural products.
Luiz F. Silva,Berit Olofsson +1 more
TL;DR: The large diversity of high-yielding and chemoselective reactions that can be achieved, even for highly functionalized molecules, is summarized, demonstrating that hypervalent iodine reagents have become an essential tool in synthetic organic chemistry.
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Partially Modified Retro-Inverso Peptides: Development, Synthesis, and Conformational Behavior
Patent
Method for attachment of biomolecules to medical device surfaces
James R. Keogh,Paul V. Trescony +1 more
TL;DR: In this article, a method for making a medical device having at least one biomolecule immobilized on a substrate surface is provided, which can be used to crosslink biomolecules comprising unsubstituted amide moieties in solution, thereby forming a crosslinked biomaterial or a cross linked medical device coating.
Journal ArticleDOI
Chemoselective reductive alkylation of ammonia with carbonyl compounds: synthesis of primary and symmetrical secondary amines
TL;DR: In this article, an efficient, general procedure for highly chemoselective reductive mono-alkylation of ammonia with ketones is reported, followed by in situ sodium borohydride reduction, and a straightforward workup afforded primary amines in good yield.