Journal ArticleDOI
Coronary and visceral vasoactivity associated with eating and digestion in the conscious dog.
TLDR
Modifications in regional blood flow and vasoactivity in response to eating and digestion were studied in conscious dogs after full recovery from instrumentation with ultrasonic or electromagnetic flow probes on the ascending aorta, left circumflex coronary, mesenteric, renal and iliac arteries, and miniature pressure gauges in the aortA.Abstract:
VATNER, STEPHEN F., DEAN FRANKLIN, AND ROBERT L. VAN CTTTERS. Goronmy and uixmzl uasoactioity associated with eating and digestion in the conscious dog. Am. J. Physiol. 219(5):1380-1385. 1970.-The modifications in regional blood flow and vasoactivity in response to eating and digestion were studied in conscious dogs after full recovery from instrumentation with ultrasonic or electromagnetic flow probes on the ascending aorta, left circumflex coronary, mesenteric, renal and iliac arteries, and miniature pressure gauges in the aorta. The presentation and ingestion of food by the resting conscious dog caused cardiac output (62yQ), arterial pressure (33%), heart rate ( 79y0), mesenteric resistance (4@&), and renal resistance (24y0) to increase transiently while iliac (337~) and coronary (62y0) resistance decreased transiently. Mesenteric flow began to increase within 5 min after eating and reached a peak of 132y0 b a ove control within 30-90 min (avg 55 min) and gradually returned to preprandial control levels over the next 2-6 hr. Iliac flow was decreased slightly (10%) 30-60 min postprandially as long as the dog did not walk about. Within lo-30 min renal and coronary flow and resistance returned to preprandial control levels and remained there during peak mesenteric vasodilatation.read more
Citations
More filters
Journal ArticleDOI
Intestinal blood flow.
TL;DR: The authors are indebted to Carolyn Brewer and Gaynell Barnes for their excellent clerical assistance.
Journal ArticleDOI
Physiologic hypoxia and oxygen homeostasis in the healthy intestine. A Review in the Theme: Cellular Responses to Hypoxia
TL;DR: The principles of mucosal oxygen delivery, metabolism, and end-point functional responses that result from this unique oxygenation profile are reviewed.
Journal ArticleDOI
Regulation of intestinal blood flow.
Paul J. Matheson,Paul J. Matheson,Mark A. Wilson,Mark A. Wilson,R. Neal Garrison,R. Neal Garrison +5 more
TL;DR: The purpose of this review is to summarize the current understanding regarding the regulatory mechanisms of intestinal blood flow in fasted and fed conditions and during pathological stress.
Journal ArticleDOI
Postprandial alterations in cardiovascular hemodynamics in autonomic dysfunctional states
TL;DR: The depressor effect of food ingestion was enhanced by propranolol, attenuated by indomethacin and unaffected by diphenhydramine and cimetidine, and can only partly be accounted for by release of arachidonic acid metabolites.
Journal ArticleDOI
Effect of food on hepatic blood flow: Implications in the “food effect” phenomenon
Craig K. Svensson,David J. Edwards,Paul M. Mauriello,Susan H. Barde,Ann C Foster,Robert A. Lanc,Elliott Middleton,David Lalka +7 more
TL;DR: Computer simulations suggest that simple changes in QH alone cannot account for the increase in apparent oral bioavailability when propranolol is taken with food.
References
More filters
Journal ArticleDOI
A Pulsed Ultrasonic Flowmeter
TL;DR: In this article, a pulsed ultransonic flowmeter was developed specifically for the simultaneous measurement of blood flow through various major blood vessels in the intact unanesthetized animal, where piezoelectric crystals were mounted on the flow section so that bursts of 3-mc sound may be transmitted alternately upstream and downstream.
Journal ArticleDOI
Effect of Digestion on Distribution of Blood Flow in the Rat
Journal ArticleDOI
The effect of distention of abdominal viscera: on the coronary blood flow and on angina pectoris
TL;DR: The incidence of anginal pain following the ingestion of food has been commented on by most of the writers on angina pectoris, and it is considered that the pain was of neuromuscular origin, consequent on gas under pressure in a hollow viscus.
Journal ArticleDOI
Hemodynamic effects of carbohydrate and protein meals in man: rest and exercise.
G R Dagenais,A Oriol,M McGregor +2 more
Journal ArticleDOI
Role of the gastrointestinal tract in production of cardiac symptoms: experimental and clinical observations
TL;DR: On intensive therapy directed to the gastrointestinal tract much better clinical results were obtained for the first time in the diminution of the frequency and intensity of paroxysms of anginal pain.