Open AccessJournal Article
[Corticobasal degeneration: symptomatological, brain-imaging and electrophysiological studies].
Mitsunori Morimatsu,Negoro K +1 more
TLDR
Eight cases of clinically diagnosed corticobasal degeneration were studied with reference to their symptomatology, brain-imagings and electrophysiological findings, and magnetic resonance imaging and SPECT findings were used to reinforce the diagnosis.Abstract:
Eight cases of clinically diagnosed corticobasal degeneration (CBD) were studied with reference to their symptomatology, brain-imagings and electrophysiological findings. The diagnosis was based on the combination of limb-kinetic apraxia (cortical sign), akinetic-rigid sign (extrapyramidal) and their unilateral predominance. Magnetic resonance imaging (MRI) and 123I-IMP or 99mTc-HMPAO SPECT findings were used to reinforce the diagnosis. The age at onset of 8 cases (4 males, 4 females) was 61 to 80 years (mean 66). Other common symptoms on admission consisted of dysequilibrium (8 cases), dysarthria (8), grasp reflex (6), supranuclear gaze palsy (6), tremor (6), limb dystonia (6) and alien limbs (5). MRI revealed parietal (3 cases) or frontoparietal (3) atrophy. SPECT showed decrease in cerebral blood flow in frontoparietal (3 cases) or frontoparietotemporal lobes (5). SPECT surpassed MRI to detect unilateral predominance of the lesions. With magnetic stimulation of the head and neck central motor conduction time (CMCT) was normal, while motor inhibitory periods (IPs) were significantly shorter in CBD patients compared with those in normal controls and the patients with Parkinson's disease. In 3 patients with reflex myoclonus, giant SEPs were not evoked, though with positive C-reflex, suggesting an elevated excitability of cerebral cortex unrelated to the production of giant SEPs.read more
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Apraxia in movement disorders
Cindy Zadikoff,Anthony E. Lang +1 more
TL;DR: It is not clear how milder ideomotor apraxia found on specific testing contributes to patients' overall day-to-day motor disability, and clinical-pathological correlates and functional imaging studies are compromised by both this diffuse involvement and the confusion experienced in the clinical evaluation ofApraxia.
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Diagnostic significance of tau protein in cerebrospinal fluid from patients with corticobasal degeneration or progressive supranuclear palsy
Katsuya Urakami,Koichi Wada,Hiroyuki Arai,Hiroshi Sasaki,Mitsuyasu Kanai,Mikio Shoji,Hideki Ishizu,Kenichi Kashihara,Mitsutoshi Yamamoto,K. Tsuchiya-Ikemoto,Mitsunori Morimatsu,Hiroshi Takashima,Masanori Nakagawa,Katsumi Kurokawa,Hirofumi Maruyama,Yumiko Kaseda,S. Nakamura,Kazuko Hasegawa,H. Oono,C. Hikasa,Kazuyuki Ikeda,Kaoru Yamagata,Yosuke Wakutani,Takao Takeshima,Kenji Nakashima +24 more
TL;DR: Using data obtained from a larger number of disease cases, it is confirmed that tau protein levels in cerebrospinal fluids in Patients with CBD are significantly higher than those in patients with PSP.
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A comparison of tau protein in cerebrospinal fluid between corticobasal degeneration and progressive supranuclear palsy
Katsuya Urakami,M. Mori,Kenji Wada,Hisanori Kowa,Takao Takeshima,Hiroyuki Arai,Hidetada Sasaki,Mitsuyasu Kanai,Mikio Shoji,Kaoru Ikemoto,Mitsunori Morimatsu,Chikanori Hikasa,Kenji Nakashima +12 more
TL;DR: Evaluated the usefulness of tau proteins in cerebrospinal fluid (CSF) for the differentiation of corticobasal degeneration (CBD) and progressive supranuclear palsy (PSP) and suggested that the measurement of CSF t Tau proteins may be useful for the differentiate between CBD and PSP.
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Limb contractures in levodopa-responsive parkinsonism : a clinical and investigational study of seven new cases
TL;DR: It is concluded that hand and feet contractures are not necessarily restricted to parkinson plus syndromes and may complicate otherwise typical PD in the absence of a structural or peripheral nervous cause.
Journal ArticleDOI
Proton magnetic resonance spectroscopy in corticobasal degeneration and progressive supranuclear palsy
Kiyoshi Negoro,Yukiko Tada,Jun-ichi Ogasawara,Motoharu Kawai,Mitsunori Morimatsu,Masahiro Hashida,Syuichi Yamauchi +6 more
TL;DR: Evaluated whether localized, single‐voxel proton magnetic resonance spectroscopy (1H‐MRS) could distinguish between typical CBD and PSP patients.