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Cost-effectiveness of adding decolonization to a surveillance strategy of screening and isolation for methicillin-resistant Staphylococcus aureus carriers

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TLDR
A strong economic argument is provided for adding an MRSA decolonization protocol to the current VHA active surveillance strategy, as well as a common strategy of no surveillance.
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This article is published in Clinical Microbiology and Infection.The article was published on 2010-12-01 and is currently open access. It has received 30 citations till now. The article focuses on the topics: Cost effectiveness.

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Journal ArticleDOI

Decolonization in Prevention of Health Care-Associated Infections

TL;DR: The strongest evidence for decolonization is for use among surgical patients as a strategy to prevent surgical site infections and additional studies are needed to assess resistance to these agents, especially selection for resistance among Gram-negative organisms.
Journal ArticleDOI

Screening, isolation, and decolonisation strategies in the control of meticillin resistant Staphylococcus aureus in intensive care units: cost effectiveness evaluation

TL;DR: In this paper, the authors assess the cost effectiveness of screening, isolation, and decolonisation strategies in the control of meticillin resistant Staphylococcus aureus (MRSA) in intensive care units.

Screening, isolation, and decolonisation strategies in the control of meticillin resistant Staphylococcus aureus in intensive care units : cost effectiveness evaluation

TL;DR: Although universal decolonisation (regardless of MRSA status) was the most cost effective in the short term, strategies using screening to target MRSA carriers may be preferred owing to the reduced risk of selecting for resistance, and combining universal screening using polymerase chain reaction withDecolonisation is likely to represent good value for money if untargeted decolonisations is considered unacceptable.
Journal ArticleDOI

Economic Features of Antibiotic Resistance: The Case of Methicillin-Resistant Staphylococcus aureus

TL;DR: The reviewed studies found that rapid MRSA detection, using molecular techniques, is an efficient technique to control MRSA and linezolid seems to be a cost-effective treatment.
Journal ArticleDOI

Cost savings of universal decolonization to prevent intensive care unit infection: implications of the REDUCE MRSA trial.

TL;DR: A strategy of universal decolonization for patients admitted to the ICU would both reduce bloodstream infections and likely reduce healthcare costs compared with strategies of MRSA nares screening and isolation or screened and isolation coupled with targeted decolonized.
References
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National Hospital Discharge Survey

TL;DR: National estimates of the use of non-Federal short-stay hospitals in the United States during 1995 are presented by demographic characteristics of patients discharged, geographic region of hospitals, conditions diagnosed, and surgical and nonsurgical procedures performed.
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Toward Causal Inference With Interference.

TL;DR: This article considers a population of groups of individuals where interference is possible between individuals within the same group, and proposes estimands for direct, indirect, total, and overall causal effects of treatment strategies in this setting.
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Universal screening for methicillin-resistant Staphylococcus aureus at hospital admission and nosocomial infection in surgical patients.

TL;DR: A universal, rapid MRSA admission screening strategy did not reduce nosocomial MRSA infection in a surgical department with endemic MRSA prevalence but relatively low rates of MRSA infections.
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Risk of Methicillin-Resistant Staphylococcus aureus Infection after Previous Infection or Colonization

TL;DR: The 18-month risk of MRSA infection among 209 adult patients newly identified as harboring MRSA was determined and patients developed subsequent MRSA infections, which were often severe.
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Eradication of Methicillin-Resistant Staphylococcus aureus Carriage: A Systematic Review

TL;DR: Short-term nasal application of mupirocin is the most effective treatment for eradicating methicillin-resistant S. aureus carriage, with an estimated success of rate of 90% 1 week after treatment and approximately 60% after a longer follow-up period.
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