COUP-TF-interacting protein-2 (Ctip2): driving the coupé of sphingolipid biosynthesis in the epidermis.
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In this issue Indra and colleagues show that Ctip2 has a key role in sphingolipid metabolism, and normalities in C Tip2 could underlie skin disorders characterized by an aberrant epidermal permeability barrier.About:
This article is published in Journal of Investigative Dermatology.The article was published on 2013-03-01 and is currently open access. It has received 2 citations till now. The article focuses on the topics: Chicken ovalbumin upstream promoter-transcription factor & Transcription factor.read more
Citations
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Bcl11b-A Critical Neurodevelopmental Transcription Factor-Roles in Health and Disease.
Matthew J. Lennon,Simon Jones,Michael D. Lovelace,Gilles J. Guillemin,Bruce J. Brew,Bruce J. Brew +5 more
TL;DR: This review summarizes the current literature on Bcl11b and its functions in development, health, and disease as well as future directions for research.
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Bcl11b/Ctip2 in Skin, Tooth, and Craniofacial System.
TL;DR: Genome-wide association studies that suggest a potential influence of single nucleotide polymorphisms found in the 3’ regulatory region of Bcl11b on the homeostasis of the cardiovascular system are discussed.
References
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Skin Barrier Disruption - A Requirement for Allergen Sensitization?
TL;DR: The notion that diseases arise from the dynamic crosstalk that occurs between the skin barrier and immune system using atopic dermatitis or eczema as the disease prototype is introduced.
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Pathogenesis of permeability barrier abnormalities in the ichthyoses: inherited disorders of lipid metabolism
TL;DR: The barrier abnormality provokes the clinical phenotype in these disorders not only by stimulating epidermal proliferation, but also by inducing inflammation.
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Omega-O-acylceramide, a lipid essential for mammalian survival.
TL;DR: Results indicate not only that acylCer are critical lipid components for mammalian survival, but also that keratinocytes deploy a complex metabolic pathway leading to the formation of these unique Cer.
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Omega-Hydroxyceramides are Required for Corneocyte Lipid Envelope (CLE) Formation and Normal Epidermal Permeability Barrier Function
Martin J. Behne,Yoshikazu Uchida,Taisuke Seki,Paul R. Ortiz de Montellano,Peter M. Elias,Walter M. Holleran,Walter M. Holleran +6 more
TL;DR: Results provide the first direct evidence for the importance of omega-OHCer for epidermal permeability function, and suggest further that acylCer and/or corneocyte lipid envelope are required elements in permeability barrier homeostasis.
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Aloxe3 knockout mice reveal a function of epidermal lipoxygenase-3 as hepoxilin synthase and its pivotal role in barrier formation.
Peter Krieg,Sabine Rosenberger,Silvia de Juanes,Susanne Latzko,Jin Hou,Angela Dick,Ulrich Kloz,Frank van der Hoeven,Ingrid Hausser,Irene Esposito,Manfred Rauh,Holm Schneider +11 more
TL;DR: Skin lipid analysis demonstrated that the severity of barrier failure is related to the loss of covalently bound ceramides in both 12R- LOX- and eLOX-3-null mice, confirming a proposed functional linkage of the LOX pathway to ceramide processing and formation of the corneocyte lipid envelope.