Journal ArticleDOI
Cox-2 inhibition can lead to adverse effects in a rat model for temporal lobe epilepsy.
TLDR
Despite a temporal reduction in seizure frequency with SC/PHT treatment, SC does not seem to be a suitable approach for anti-epileptogenic or anti-EPileptic therapy.About:
This article is published in Epilepsy Research.The article was published on 2010-09-01. It has received 76 citations till now. The article focuses on the topics: Epilepsy & Status epilepticus.read more
Citations
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Journal ArticleDOI
Mechanisms of epileptogenesis and potential treatment targets.
Asla Pitkänen,Katarzyna Lukasiuk +1 more
TL;DR: In this paper, molecular profiling studies have provided an insight into molecular changes that contribute to formation of ictogenic neuronal networks, including genes regulating synaptic or neuronal plasticity, cell death, proliferation, and inflammatory or immune responses.
Journal ArticleDOI
Neuroinflammatory pathways as treatment targets and biomarkers in epilepsy.
TL;DR: Understanding is focused on the IL-1 receptor–Toll-like receptor 4 axis, the arachidonic acid–prostaglandin cascade, oxidative stress and transforming growth factor-β signalling associated with blood–brain barrier dysfunction, all of which are pathways that are activated in pharmacoresistant epilepsy in humans and that can be modulated in animal models to produce therapeutic effects on seizures.
Journal ArticleDOI
The role of inflammation in epileptogenesis
TL;DR: The evidence conceptually supporting the involvement of brain inflammation and the associated blood-brain barrier damage in epileptogenesis is reviewed, and the available pharmacological evidence where post-injury intervention with anti-inflammatory drugs has been attempted is described.
Journal ArticleDOI
The role of inflammation in the development of epilepsy
Amna Z Rana,Alberto E. Musto +1 more
TL;DR: Understanding the neurobiology of inflammation in epileptogenesis will contribute to the development of new biomarkers for better screening of patients at risk for epilepsy and new therapeutic targets for both prophylaxis and treatment of epilepsy.
Journal ArticleDOI
Drug Resistance in Epilepsy: Clinical Impact, Potential Mechanisms, and New Innovative Treatment Options.
TL;DR: The current understanding of the molecular, genetic, and structural mechanisms of drug resistance in epilepsy and how the problem might be overcome are reviewed.
References
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Book
The Rat Brain in Stereotaxic Coordinates
George Paxinos,Charles Watson +1 more
TL;DR: This paper presents a meta-analyses of the determinants of earthquake-triggered landsliding in the Czech Republic over a period of 18 months in order to establish a probabilistic framework for estimating the intensity of the earthquake.
Journal ArticleDOI
Modification of seizure activity by electrical stimulation. II. Motor seizure.
TL;DR: It was found that the development of motor seizures by stimulation of the amygdala resulted in an increased ability of the contralateral amygdala, and the septal area, but not of the hippocampus, to drive motor seizures when stimulated (“transfer”).
Journal ArticleDOI
Cyclooxygenase Isozymes: The Biology of Prostaglandin Synthesis and Inhibition
TL;DR: Characterization of the two COX isozymes is allowing the discrimination of the roles each play in physiological processes such as homeostatic maintenance of the gastrointestinal tract, renal function, blood clotting, embryonic implantation, parturition, pain, and fever.
Journal ArticleDOI
Brain inflammation in epilepsy: experimental and clinical evidence.
TL;DR: The possibility that inflammation may be a common factor contributing, or predisposing, to the occurrence of seizures and cell death, in various forms of epilepsy of different etiologies is discussed.
Journal ArticleDOI
Innate and adaptive immunity during epileptogenesis and spontaneous seizures: Evidence from experimental models and human temporal lobe epilepsy
Teresa Ravizza,Barbara Gagliardi,Francesco Noé,Karin de Boer,Eleonora Aronica,Annamaria Vezzani +5 more
TL;DR: Data show that specific inflammatory pathways are chronically activated during epileptogenesis and they persist in chronic epileptic tissue, suggesting they may contribute to the etiopathogenesis of TLE.