Journal ArticleDOI
Current Recommendations for Bladder Instillation Therapy in the Treatment of Interstitial Cystitis/Bladder Pain Syndrome
Marc Colaco,Robert J. Evans +1 more
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TLDR
The purpose of this review is to examine the evidence behind the recommendations for dimethyl sulfoxide, heparin, and lidocaine and several historical or experimental therapies that do not hold recommendations but are still used on rare occasion.Abstract:
Bladder instillation therapy refers to the direct introduction of medication into the bladder and is a common treatment modality for patients with interstitial cystitis/bladder pain syndrome (IC/BPS) who have failed conservative and oral therapies. The current American Urological Association (AUA) recommendations list three medications as options for IC/BPS instillation therapy: dimethyl sulfoxide, heparin, and lidocaine. The purpose of this review is to examine the evidence behind the recommendations for these medications. We also examine several historical or experimental therapies that do not hold recommendations but are still used on rare occasion. Finally, we discuss our bladder instillation strategies as well as potential future research and development in intravesicular therapy.read more
Citations
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Journal ArticleDOI
Novel targeted bladder drug-delivery systems: a review.
TL;DR: This review focuses on novel DDSs to treat bladder conditions such as overactive bladder, interstitial cystitis, bladder cancer, and recurrent urinary tract infections, with emphasis on new formulations of well-known drugs (oxybutynin), nanocarriers, polymeric hydrogels, intravesical devices, encapsulated D DSs, and gene therapy.
Journal ArticleDOI
First evidence of neosaxitoxin as a long-acting pain blocker in bladder pain syndrome.
Valentín Manríquez,Daniela Castro Caperan,Rodrigo Guzmán,Michel Naser,Veronica Iglesia,Néstor Lagos +5 more
TL;DR: Neosaxitoxin infiltration was shown to be a safe and effective intervention to control pain related to BPS and was well tolerated by patients, who experienced extended pain relief and associated beneficial effects over a follow-up of 90 days.
Journal ArticleDOI
Current guidelines in the management of interstitial cystitis
Marc Colaco,Robert J. Evans +1 more
TL;DR: The purpose of this review is to outline the recommendations for the treatment of IC and the evidence from which these recommendations arise and to examine the most up to date literature so that future directions in the Treatment of IC may be recognized.
Journal ArticleDOI
An update on treatment options for interstitial cystitis.
Simone Garzon,Antonio Simone Laganà,Jvan Casarin,Ricciarda Raffaelli,Antonella Cromi,Davide Sturla,Massimo Franchi,Fabio Ghezzi +7 more
TL;DR: Only further investigation on the etiopathogenetic mechanisms, taking into account the differences among subgroups, and the interaction between central and peripherical factors may allow providing a real improvement in the treatment and management of patients with IC/BPS.
Journal ArticleDOI
Bladder Pain Syndrome.
TL;DR: In this paper, the authors discuss the common cause of chronic pelvic pain with associated lower urinary symptoms, and suggest dietary changes (avoiding acidic, spicy, and caffeinated foods) are effective at relieving symptoms.
References
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Journal ArticleDOI
Incidence and treatment of complications of bacillus Calmette-Guerin intravesical therapy in superficial bladder cancer.
Donald L. Lamm,Ad P.M. Van Der Meijden,Alvaro Morales,Stanley A. Brosman,William J. Catalona,Harry W. Herr,Mark S. Soloway,Adolphe Steg,Frans M.J. Debruyne +8 more
TL;DR: Recognition of risk factors, particularly traumatic catheterization or concurrent cystitis, that result in systemic BCG absorption, as well as the prompt and appropriate treatment of early side effects should significantly decrease the incidence of severe toxicity.
Journal ArticleDOI
AUA guideline for the diagnosis and treatment of interstitial cystitis/bladder pain syndrome.
Philip M. Hanno,David Burks,J. Quentin Clemens,Roger Dmochowski,Deborah R. Erickson,Mary P. FitzGerald,John B. Forrest,Barbara Gordon,Mikel Gray,Robert D. Mayer,Diane K. Newman,Leroy Jr. Nyberg,Christopher K. Payne,Ursula Wesselmann,Martha M. Faraday +14 more
TL;DR: Interstitial cystitis/bladder pain syndrome is best identified and managed through use of a logical algorithm such as is presented in this Guideline.
Journal ArticleDOI
Intravesical capsaicin and resiniferatoxin therapy: spicing up the ways to treat the overactive bladder
TL;DR: Intravesical capsaicin and resiniferatoxin are novel and promising treatments for the overactive bladder, with profound basic and clinical implications.
Journal ArticleDOI
Treatment of interstitial cystitis with intravesical heparin.
TL;DR: In over half of the patients studied, intravesical heparin controls the symptoms of interstitial cystitis with continued improvement even after one year of therapy.
Journal ArticleDOI
Intravesical resiniferatoxin for the treatment of interstitial cystitis: a randomized, double-blind, placebo controlled trial.
Christopher K. Payne,Philip G. Mosbaugh,John B. Forrest,Robert J. Evans,Kristene E. Whitmore,Joseph P. Antoci,Ramon Perez-Marrero,Karny Jacoby,Ananias C. Diokno,Keith J. O’Reilly,Tomas L. Griebling,Sandip P. Vasavada,Albert S. Yu,Lyn R. Frumkin +13 more
TL;DR: In the largest prospective, randomized clinical trial reported to date with intravesical vanilloid therapy, single administration of RTX at doses of 0.01 microM to 0.10 microM was not effective in patients with interstitial cystitis.