Journal ArticleDOI
Cyclic 3',5'-nucleotide phosphodiesterase. Demonstration of an activator.
W Y Cheung,W Y Cheung +1 more
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TLDR
In this paper, a mixture of a purified and a crude cyclic 3′,5′-nucleotide phosphodiesterase was shown to have higher activity than the summed activities of the individual preparations.About:
This article is published in Biochemical and Biophysical Research Communications.The article was published on 1970-02-06. It has received 773 citations till now. The article focuses on the topics: Phosphodiesterase & Activator (genetics).read more
Citations
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Calmodulin plays a pivotal role in cellular regulation
TL;DR: The role of calcium ions (Ca2+) in cell function is beginning to be unraveled at the molecular level as a result of recent research on calcium-binding proteins and particularly on calmodulin.
Journal ArticleDOI
Cyclic Nucleotide Phosphodiesterases: Molecular Regulation to Clinical Use
Andrew T. Bender,Joseph A. Beavo +1 more
TL;DR: Basic biochemical properties, cellular regulation, expression patterns, and physiological functions of the different PDE isoforms will be discussed and how these properties relate to the current and future development of PDE inhibitors as pharmacological agents is especially considered.
Journal ArticleDOI
Calcium-dependent activation of a multifunctional protein kinase by membrane phospholipids.
TL;DR: The proenzyme of a Ca2+-dependent protease-activated protein kinase previously obtained from mammalian tissues showed an ability to phosphorylate five histone fractions and muscle phosphorylase kinase, and appeared to possess multifunctional catalytic activities.
Journal ArticleDOI
The role of protein phosphorylation in neural and hormonal control of cellular activity
TL;DR: There is an integrated network of regulatory pathways, mediated by phosphorylation–dephosphorylation, that allows diverse cellular events to be coordinated by neural and hormonal stimuli, and the evidence that supports this concept is reviewed.
Journal ArticleDOI
Calcium: A Central Regulator of Plant Growth and Development
TL;DR: Today no one questions the assertion that Ca2+ is a crucial regulator of growth and development in plants.
References
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Journal ArticleDOI
Adenosine 3',5'-phosphate in biological materials. I. Purification and properties of cyclic 3',5'-nucleotide phosphodiesterase and use of this enzyme to characterize adenosine 3',5'-phosphate in human urine.
R.W. Butcher,Earl W. Sutherland +1 more
TL;DR: Data indicated a significant role for the enzyme in the control of the levels of adenosine 3’,5’-phosphate present in biological systems, which was very desirable because of the extremely low levels present in most biological materials.
Journal ArticleDOI
Properties of cyclic 3',5'-nucleotide phosphodiesterase from rat brain.
Journal ArticleDOI
Cyclic 3',5'-nucleotide phosphodiesterase. Preparation of a partially inactive enzyme and its subsequent stimulation by snake venom.
Wai Yiu Cheung,Wai Yiu Cheung +1 more
TL;DR: Although venom exhibited tryptic activity, neither its tryptic nor stimulatory activity was affected by trypsin inhibitor, and activation of phosphodiesterase by venom appeared to be monomolecular reaction and was not dependent on Mn 2+ at a concentration optimal for phosphodiestersterase activity.
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Calcium dependent phosphodiesterase activity and its activating factor (PAF) from brain studies on cyclic 3',5'-nucleotide phosphodiesterase (3).
Shiro Kakiuchi,Reiko Yamazaki +1 more