Journal ArticleDOI
Cyclic AMP levels in fibroblasts: relationship to growth rate and contact inhibition of growth.
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TLDR
There is an inverse correlation between growth rate and cyclic AMP levels and contact inhibition of growth in cultured fibroblasts when many lines are compared during logarithmic growth.About:
This article is published in Biochemical and Biophysical Research Communications.The article was published on 1971-09-03. It has received 412 citations till now. The article focuses on the topics: Contact inhibition & Confluency.read more
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Trans-membrane control of the receptors on normal and tumor cells. II. Surface changes associated with transformation and malignancy.
Journal ArticleDOI
Effect of insulin on the proliferation of cultured primate arterial smooth muscle cells.
TL;DR: Insulin in concentrations of 10, 100, 1,000, and 10,000 μunits/ml resulted in successively greater stimulation of growth which was highly significant and significant by analysis of variance and there was a significant linear relationship between the logarithm of the insulin dose and cell growth.
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Changes in surface morphology of chinese hamster ovary cells during the cell cycle
TL;DR: Synchronized populations of Chinese hamster ovary (CHO) cells in confluent culture have been examined by scanning electron microscopy and their surface changes noted as the cells progress through the cycle reflect the changing capacity of CHO cells during the cycle to respond to contact with other cells in the population.
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Difference in the Cyclic Adenosine 3′,5′-Monophosphate Levels in Normal and Transformed Cells
TL;DR: Dibutyryl cyclic AMP has been shown to restore controlled growth to transformed cells3, change the cell's surface architecture3, and induce axon formation with an accompanied increase in acetylcholinesterase activity in neuroblastoma cells growing in culture, suggesting that the cyclicAMP moiety may have some basic regulatory action on cell growth and cell specialization.
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Journal Article
Protein Measurement with the Folin Phenol Reagent
TL;DR: Procedures are described for measuring protein in solution or after precipitation with acids or other agents, and for the determination of as little as 0.2 gamma of protein.
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Density Dependent Inhibition of Cell Growth in Culture
Michael Stoker,Harry Rubin +1 more
TL;DR: It was found that certain sarcoma cells were less sensitive to inhibition than normal fibroblasts, and that they moved freely over one another and over normal cells3.
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Reduced Adenyl Cyclase Activity in a Polyoma Virus Transformed Cell Line
TL;DR: In this article, the authors present indirect evidence that increased levels of cyclic-AMP may decrease cell growth in culture and describes an attempt to test the hypothesis that the regulation of cyclIC-AMP levels differs in normal and virus transformed cells.
Journal Article
Cyclic nucleotides on cell growth in vitro.
TL;DR: The growth of four tumorigenic cell lines was inhibited from 70 to 89% by adenosine 3′, 5′-cyclic monophosphate whereas a nonmalignant cell line (WI-38) was affected only slightly (13%).