Journal ArticleDOI
CYP17 gene polymorphic sequence variation is associated with hyperandrogenism in Kashmiri women with polycystic ovarian syndrome.
Sairish Ashraf,Shayaq Ul Abeer Rasool,Mudasar Nabi,Mohd Ashraf Ganie,Farhat Jabeen,Fouzia Rashid,Shajrul Amin +6 more
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TLDR
PCOS patients with mutant genotype had significantly higher level of total testosterone and clinical features like FG score, alopecia than those of wild and heterozygous genotype, indicating association with hyperandrogenism in Kashmiri population.Abstract:
Polycystic ovarian syndrome is a complex reproductive as well as endocrinological disorder characterized by anovulatory dysfunction, androgen excess and polycystic ovarian morphology. Hyperandrogen...read more
Citations
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A Review on CYP11A1, CYP17A1, and CYP19A1 Polymorphism Studies: Candidate Susceptibility Genes for Polycystic Ovary Syndrome (PCOS) and Infertility
Roozbeh Heidarzadehpilehrood,Maryam Pirhoushiaran,Rasoul Abdollahzadeh,Malina Binti Osman,Maryam Sakinah,Norshariza Nordin,Habibah Abdul Hamid +6 more
TL;DR: This study strongly suggests that the CYP11A1, CYP17A 1, and CYP19A1 genes might significantly enhance the probability of developing PCOS with infertility.
Journal ArticleDOI
Exposure to bisphenol A and its analogs and polycystic ovarian syndrome in women of childbearing age: A multicenter case-control study.
TL;DR: Wang et al. as mentioned in this paper found that mixed exposure to seven bisphenol analogs was associated with increased odds of polycystic ovarian syndrome (PCOS), which was primarily driven by BPA, BPS, BPZ, and BPAF.
Journal ArticleDOI
An update on polycystic ovary syndrome: A review of the current state of knowledge in diagnosis, genetic etiology, and emerging treatment options
TL;DR: The most recent research done to establish relationships between different gene polymorphisms with polycystic ovary syndrome in various populations along with the underestimated impact of environmental factors like endocrine-disrupting chemicals on the reproductive health of these women are looked at.
Journal ArticleDOI
The single-nucleotide polymorphism rs743572 of CYP17A1 shows significant association with polycystic ovary syndrome: a meta-analysis
TL;DR: The rs743572 T>C mutation was most likely to be associated with PCOS risk under the recessive model, and the mutant genotype CC may increase susceptibility to PCOS in Caucasians rather than Asians.
Journal ArticleDOI
Common endocrine disorders associated with the polycystic ovary syndrome.
TL;DR: In this paper, the authors suggested the screening of polycystic ovary syndrome (PCOS) women for hypothyroidism and hyperprolactinemia, because the undiagnosed hypomethroidism can aggravate the PCOS symptoms.
References
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Journal ArticleDOI
Androgen Excess in Women: Experience with Over 1000 Consecutive Patients
Ricardo Azziz,Luis Sánchez,Eric S. Knochenhauer,Carlos Morán,J. Lazenby,K. C. Stephens,Kent D. Taylor,Larry R. Boots +7 more
TL;DR: Specific identifiable disorders (NCAH, CAH, HAIRAN syndrome, and androgen-secreting neoplasms) were observed in approximately 7% of subjects, whereas functional androgen excess, principally PCOS, was observed in the remainder.
Journal ArticleDOI
Polycystic ovaries and premature male pattern baldness are associated with one allele of the steroid metabolism gene CYP17
A. H. Carey,Dawn Waterworth,Kirty Patel,Davinia White,Julie Little,Patricia Novelli,Stephen Franks,Robert Williamson +7 more
TL;DR: Variation in the A2 allele of the CYP17 gene is a significant factor modifying the expression of PCO/MPB in families where it has been demonstrated to segregate as a single gene disorder, but it is excluded as the primary genetic defect.
Journal ArticleDOI
Geographical Prevalence of Polycystic Ovary Syndrome as Determined by Region and Race/Ethnicity.
TL;DR: This review will seek to determine the prevalence of polycystic ovary syndrome based on geographical location and race/ethnicity.
Journal ArticleDOI
Impact of obesity on infertility in women.
Zeynep Ozcan Dag,Berna Dilbaz +1 more
TL;DR: Overweight women have a higher incidence of menstrual dysfunction and anovulation, and are at a high risk for reproductive health, and weight loss has beneficial effects on the reproductive outcomes in patients.
Journal Article
CYP17 and breast cancer risk: the polymorphism in the 5' flanking area of the gene does not influence binding to Sp-1.
Vessela N. Kristensen,Ellen K. Haraldsen,Kristin B. Anderson,Per Eystein Lønning,Bjørn Erikstein,Rolf Kåresen,Odd S. Gabrielsen,Anne Lise Børresen-Dale +7 more
TL;DR: Genotyping of 510 breast cancer patients and 201 controls revealed no difference in genotype frequencies and age at onset, tumor grade, lymph node status and distant metastases, stage, and estrogen and progesterone receptor status were not associated with the CYP17 genotype.