Common endocrine disorders associated with the polycystic ovary syndrome.
TLDR
In this paper, the authors suggested the screening of polycystic ovary syndrome (PCOS) women for hypothyroidism and hyperprolactinemia, because the undiagnosed hypomethroidism can aggravate the PCOS symptoms.Abstract:
Introduction Screening of polycystic ovary syndrome (PCOS) women for hypothyroidism and hyperprolactinemia was suggested, because the undiagnosed hypothyroidism and hyperprolactinemia can aggravate the PCOS symptoms. Aim of the study To determine whether the insulin resistance (IR), hypothyroidism, and hyperprolactinemia are common endocrine disorders associated with the PCOS. Material and methods One hundred and twenty PCOS women were compared to 120 non-PCOS controls in this study. Participants' day 2-3 hormonal profile and insulin resistance (IR) using the fasting glucose and fasting insulin were evaluated. Collected data were analyzed to determine whether the IR, hypothyroidism, and hyperprolactinemia are common endocrine disorders associated with the PCOS. Results TSH and prolactin were significantly high in PCOS women (6.4 ±4.2 and 934 ±102.3, respectively) than controls (3.5 ±3.3 and 445 ±77.5 mIU/ml, respectively) (p = 0.004 and 0.001, respectively). The PCOS women had significantly high relative risk of IR (RR 3.0 (95% CI: 1.9-4.7) p < 0.0001), hypothyroidism (RR 3.4; 95% CI: 1.7-6.9) (p = 0.0005), and hyperprolactinaemia (RR 3.15; 95% CI: 1.8-5.6) (p = 0.0001) than controls. The PCOS women had higher odds of IR (OR 4.8; 95% CI: 2.6-8.8) (p < 0.0001), hypothyroidism (OR 4.29; 95% CI: 1.9-9.4) (p = 0.0003), and hyperprolactinaemia (OR 4.27; 95% CI: 2.1-8.5) (p < 0.0001) than controls. Conclusions TSH and prolactin were significantly high in studied PCOS women, and 47.5% of the studied PCOS women had IR. The PCOS women had significantly higher odds and relative risks of IR, hypothyroidism, and hyperprolactinemia than controls. IR, hypothyroidism, and hyperprolactinemia are common endocrine disorders associated with PCOS.read more
Citations
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Bifidobacterium Is Enriched in Gut Microbiome of Kashmiri Women with Polycystic Ovary Syndrome
TL;DR: In this paper , the authors investigated the relationship between gut microbiome composition and polycystic ovarian syndrome (PCOS) with links to specific reproductive health metabolic and hormonal predictors in Indian women.
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Sildenafil citrate as an adjuvant to clomiphene citrate for ovulation induction in polycystic ovary syndrome: crossover randomized controlled trial
TL;DR: SC as an adjuvant to CC for OI in PCOS women increases the chemical and clinical pregnancy rates and improves the endometrial thickness and ovulation rate through improved endometrian and ovarian Doppler indices.
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Sildenafil citrate as an adjuvant to clomiphene citrate for ovulation induction in polycystic ovary syndrome: crossover randomized controlled trial
TL;DR: In this paper , sildenafil citrate was used as an adjuvant to clomiphene citrate (CC) for ovulation induction in women with polycystic ovary syndrome (PCOS).
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The impact of primary dysmenorrhea on the adolescents` activities and school attendance
TL;DR: In this paper , a trans-abdominal pelvic ultrasound was performed on one hundred and eighty adolescents between 12-18 years-old with primary dysmenorrhea, and the Pearson's correlation was used to detect the relation between the severity of dysmenorhea and its negative impact on the adolescents' activities, and school attendance.
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Evaluation of the relationship between serum TSH levels and pregnancy outcomes of IVF/ICSI patients in follicular phase long-acting long protocol
TL;DR: The higher implantation and miscarriage rates of D3 of IVF/ICSI in the follicular phase long-acting long protocol may be related to higher serum TSH levels.
References
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Journal ArticleDOI
Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome
TL;DR: Since the 1990 NIH-sponsored conference on polycystic ovary syndrome, it has become appreciated that the syndrome encompasses a broader spectrum of signs and symptoms of ovarian dysfunction than those defined by the original diagnostic criteria.
Journal ArticleDOI
Recommendations from the international evidence-based guideline for the assessment and management of polycystic ovary syndrome
Helena J. Teede,Helena J. Teede,Marie Misso,Marie Misso,Michael F. Costello,Anuja Dokras,Joop S.E. Laven,Lisa J. Moran,Lisa J. Moran,Terhi Piltonen,Robert J. Norman,Robert J. Norman,Marianne Andersen,Ricardo Azziz,Adam H. Balen,Estifanos Baye,Jacqueline Boyle,Leah Brennan,Frank J.M. Broekmans,Preeti Dabadghao,Luigi Devoto,Didier Dewailly,Linda Downes,Bart C.J.M. Fauser,Stephen Franks,Rhonda Garad,Melanie Gibson-Helm,Cheryce L. Harrison,Roger Hart,Rachel Hawkes,Angelica Lindén Hirschberg,Kathleen M. Hoeger,Femke P Hohmann,Samantha K. Hutchison,Anju E. Joham,Louise Johnson,Cailin Jordan,Jayashri Kulkarni,Richard S. Legro,Rong Li,Marla E. Lujan,Jaideep Malhotra,Darren Mansfield,Kate Marsh,Veryan McAllister,Edgar Mocanu,Ben W.J. Mol,Ernest Hung Yu Ng,Sharon E. Oberfield,Sasha Ottey,Alexia S Peña,Jie Qiao,Leanne M. Redman,Raymond J. Rodgers,Luk Rombauts,Daniela Romualdi,Duru Shah,Jane Speight,Poli Mara Spritzer,Elisabet Stener-Victorin,Nigel K. Stepto,Juha S. Tapanainen,Eliza C. Tassone,Shakila Thangaratinam,Mala Thondan,Chii Ruey Tzeng,Zephne M van der Spuy,Eszter Vanky,Maria G. Vogiatzi,Angela Wan,Chandrika N Wijeyaratne,Selma F. Witchel,Jane Woolcock,Bulent O. Yildiz +73 more
TL;DR: The international guideline for the assessment and management of PCOS provides clinicians with clear advice on best practice based on the best available evidence, expert multidisciplinary input and consumer preferences to promote consistent, evidence-based care and improve the experience and health outcomes of women with PCOS.
Journal ArticleDOI
Serum prolactin and TSH in an in vitro fertilization population: is there a link between fertilization and thyroid function?
Daniel W. Cramer,Patrick M. Sluss,R. D. Powers,Patricia M. McShane,Elizabeth S. Ginsburg,Mark D. Hornstein,Allison F. Vitonis,Robert L. Barbieri +7 more
TL;DR: Investigating whether prolactin or TSH predicted outcome in a prospective study of couples undergoing IVF between 1994 and 2001 concluded that TSH may predict poor fertilization in IVF and reflect the importance of thyroid hormones in oocyte physiology.
Journal ArticleDOI
Distinct subtypes of polycystic ovary syndrome with novel genetic associations: An unsupervised, phenotypic clustering analysis.
Matthew Dapas,Frederick T.J. Lin,Girish N. Nadkarni,Ryan Sisk,Richard S. Legro,Margrit Urbanek,M. Geoffrey Hayes,Andrea Dunaif +7 more
TL;DR: The results suggest that these subtypes of PCOS are biologically relevant because they appear to have distinct genetic architecture, and demonstrates how phenotypic subtyping can be used to gain additional insights from GWAS data.
Incidence of elevated LH/FSH ratio in polycystic ovary syndrome women with normo- and hyperinsulinemia.
TL;DR: LH/FSH ratio is not a characteristic attribute of all PCOS women: in the present study this abnormality was detected in a subpopulation smaller than 50%.
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