Journal ArticleDOI
Δ5-3β-Hydroxysteroid acyl transferase activity in the rat brain
Claire Vourc'h,Bernard Eychenne,Do-Hyun Jo,Jeanine Raulin,Danielle Lapous,Etienne-Emile Baulieu,Paul Robel +6 more
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TLDR
In this paper, the steroid fatty acid ester-synthesizing activity was investigated in rat brain microsomes, and a high level of synthetic activity was found in the brain of 1-to 3-week-old male rats, which rapidly decreased with aging.About:
This article is published in Steroids.The article was published on 1992-05-01. It has received 27 citations till now. The article focuses on the topics: Pregnenolone & Fatty acid.read more
Citations
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Journal ArticleDOI
Neurosteroids: a novel function of the brain.
TL;DR: A physiological function of neurosteroids in the central nervous system is strongly suggested by the role of hippocampal PREGS with respect to memory, observed in aging rats and it may be important to study the effect of abnormal neurosteroid concentrations/metabolism with a view to the possible treatment of functional and trophic disturbances of the nervous system.
Journal Article
Neurosteroids: Expression of Steroidogenic Enzymes and Regulation of Steroid Biosynthesis in the Central Nervous System
Ayikoe Guy Mensah-Nyagan,Jean-Luc Do-Rego,Delphine Beaujean,Van Luu-The,Georges Pelletier,Hubert Vaudry +5 more
TL;DR: Steroid hormones, which are synthesized in the adrenal gland, gonads and placenta, exert a large array of biological effects on the nervous system, including development, growth, maturation, and differentiation of the central nervous system.
Book ChapterDOI
Neurosteroids: Beginning of the story
TL;DR: A physiological function of neurosteroids in the central nervous system is strongly suggested by the role of hippocampal PREGS with respect to memory performance, observed in aging rats, and a new mechanism of PREG action discovered in the brain involves specific steroid binding to microtubule associated protein and increased tubulin polymerization for assembling microtubules.
Journal ArticleDOI
Neurosteroids: Biosynthesis and Function
Paul Robel,Etienne-Emile Baulieu +1 more
TL;DR: The term neurosteroids applies to those steroids that are both synthesized in the nervous system, either de novo from cholesterol or from steroid hormone precursors, and that accumulate in the central nervous system to levels that are at least in part independent of steroidogenic gland secretion rates as discussed by the authors.
Journal ArticleDOI
Neurosteroids: a new function in the brain.
TL;DR: Preliminary findings suggest that the neurosteroid concept applies to all mammalian species, including man, and the pathophysiological significance of the synthesis of neurosteroids should be assessed.
References
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Journal ArticleDOI
Characterization and measurement of dehydroepiandrosterone sulfate in rat brain.
TL;DR: It is proposed that Ia formation or accumulation in the rat brain depends on in situ mechanisms unrelated to the peripheral endocrine gland system.
Journal ArticleDOI
Neurosteroids: cytochrome P-450scc in rat brain
TL;DR: Observations strongly support the existence of "neurosteroids," which have been posited on the basis of biochemical, physiological, and behavioral studies.
Journal ArticleDOI
Pregnenolone and its sulfate ester in the rat brain
C. Corpéchot,Monique Synguelakis,Saliha Talha,Magnus Axelson,Jan Sjövall,Reijo Vihko,Etienne-Emile Baulieu,Paul Robel +7 more
TL;DR: Brain P and PS levels did not seem to depend on steroidogenic gland secretion: no meaningful difference occurred in brain 15 days after adrenalectomy plus orchiectomy, compared with sham-operated controls and it is proposed that P andPS formation or accumulation in the rat brain depend on in situ mechanisms unrelated to the peripheral endocrine gland system.
Journal ArticleDOI
Neurosteroids: Biosynthesis of Pregnenolone and Progesterone in Primary Cultures of Rat Glial Cells*
TL;DR: The demonstration of P, pregn-5-ene-3 beta,20 alpha-diol, and progesterone synthesis by normal rat glial cells, once oligodendrocytes have undergone their differentiation process, brings additional support to the concept of "neurosteroids."
Journal ArticleDOI
Neurosteroids: oligodendrocyte mitochondria convert cholesterol to pregnenolone.
TL;DR: The active cholesterol side-chain cleavage mechanism, recently suggested immunohistochemically and already observed in cultures of C6 glioma cells, reinforces the concept of "neurosteroids" applied to delta 5-3 beta-hydroxysteroids previously isolated from brain.