Journal ArticleDOI
Dengue hemorrhagic fever in Cuba, 1981: a retrospective seroepidemiologic study.
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A retrospective seroepidemiological survey was conducted in Cerro, a densely populated district in Havana City, Cuba, finding children infected by DEN-1 virus followed byDEN-2 virus had a high risk of acquiring dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS).Abstract:
In Cuba, 2 epidemics of dengue virus occurred: 1 caused by DEN-1 in 1977 and 1 caused by DEN-2 in 1981. The latter was associated with cases of dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS). To study viral risk factors for DHF/DSS, a retrospective seroepidemiological survey was conducted in Cerro, a densely populated district in Havana City. The prevalence of plaque reduction neutralizing antibodies to DEN-1 and DEN-2 viruses was measured in 1,295 individuals (children and adults). Of these, 43.7% were immune to DEN-1 virus and 23.6% to DEN-2 virus. Of those individuals who were immune, 26.1% were immune to DEN-1 virus only, 6% to DEN-2 virus only, and 17.6% to both viruses. The DEN-2 virus infection rate in DEN-1 immune individuals was 3.8 times higher than in non-immune individuals. The 5 DHF/DSS cases in the sample had evidence of DEN-1 virus plus DEN-2 virus infections. Three were children and 2 were young adults. No cases were found in individuals infected with DEN-1 virus or DEN-2 virus only. Children infected by DEN-1 virus followed by DEN-2 virus had a high risk of acquiring DHF/DSS. Blacks and whites were equally infected with DEN-1 and DEN-2 viruses.read more
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Dengue transmission in the small-island setting: investigations from the Caribbean island of Grenada.
TL;DR: An active surveillance system supported by laboratory-based diagnosis on the small island of Grenada provided evidence of three distinct modes of disease dynamics in the form of low endemic, pre-epidemic, and overt epidemic transmission of mostly benign dengue fever.
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Dengue and land cover heterogeneity in Rio de Janeiro
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Book ChapterDOI
New approaches to flavivirus vaccine development.
TL;DR: This chapter discusses new approaches to flavivirus vaccine development and presents recent advances in the molecular biology of flaviviruses that will offer novel alternatives to further flaviv virus vaccine development.
Dengue y dengue hemorrágico, Cuba 1981-2005
Guzmán Tirado,Maria Guadalupe +1 more
TL;DR: La caracterizacion de tres epidemias de dengue ocurridas en nuestro pais en el periodo 1981-2002 asi como los estudios clinico-epidemiologicos y virologicos con relacion a las mismas are abordan como tematicas fundamentales.
Journal ArticleDOI
A DNA microarray-based assay to detect dual infection with two dengue virus serotypes.
Alvaro Diaz-Badillo,María de Lourdes Muñoz,Gerardo Pérez-Ramírez,Victor Altuzar,Juan Burgueño,J.G. Mendoza-Alvarez,Jorge P. Martínez-Muñoz,Alejandro Cisneros,Joel Navarrete-Espinosa,F. Sánchez-Sinencio +9 more
TL;DR: This DNA microarray assay is specific and sensitive and can detect dual infections with two dengue virus serotypes and single-serotype infections and provides evidence that specific probes can effectively identify single and double infections in DENV samples.