Depression following fenfluramine withdrawal.

TLDR: Grosz and Farmer as mentioned in this paper showed that an anxiety state can be induced by elevating blood lactate concentration, which is an extension and refinement of the hypothesis of Pius and McClure.

Abstract: PITTS' AND McCLURE'S LACTATE-ANXIETY STUDY REVISITED DEAR Sm, Grosz and Farmer (Journal, April 1972, 120, 4:5—8) have reported the results of an interesting study showing that anxiety symptoms can be preci pitated by the production of metabolic alkalosis. Unfortunately, they present their results as a refuta tion of the previous conclusions of Pitts and McClure (New Eng.3. Med. 1967, 27, :329—36,) that an anxiety state can be induced by elevating blood lactate concentration. It is true that the data of Grosz and Farmer, if confirmed, would lead to a new interpretation of the previous conclusions regarding blood lactate. However, these newer findings should be viewed simply as an extension and refinement of the hypothesis of Pius and McClure. The tendency in psychiatric research to view an incomplete or partially correct theory as an error discourages investi