Journal ArticleDOI
Design and synthesis of novel 1,3,4‐oxadiazole based azaspirocycles catalyzed by NaI under mild condition and evaluated their antidiabetic and antibacterial activities
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This article is published in Journal of Heterocyclic Chemistry.The article was published on 2021-02-01. It has received 21 citations till now. The article focuses on the topics: Oxadiazole.read more
Citations
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Synthesis and in vitro Antidiabetic Screening of Novel Dihydropyrimidine Derivatives
TL;DR: A series of N-substituted 6-methyl compounds have been synthesized by condensation of newly synthesized {4]-5-(4-nitrophenyl)-1,3,4-oxadiazol-2-yl]benzaldehyde with variously substituted acetoacetanilides and urea in the presence of ethanol as mentioned in this paper.
Journal ArticleDOI
Microwave-Assisted Synthesis of Some Novel 1,2,3,4-Tetrahydropyrimidine Derivatives as Antidiabetic Agents
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Heterocyclic compounds as a magic bullet for diabetes mellitus: a review
Umme Farwa,Muhammad Asam Raza +1 more
TL;DR: Data were organized for the synthesis of heterocyclic compounds through various routes along with their antidiabetic potential, and further studies such as pharmacokinetic and toxicology studies should be executed before going for clinical trials.
Journal ArticleDOI
Trimethylsilyl chloride catalyzed synthesis of fluoro substituted tetrahydropyrimidines: Molecular docking and antidiabetic studies
TL;DR: In this article , a series of tetrahydropyrimidine derivatives containing azepino indole and aryl substitution was achieved by a multicomponent synthetic approach using Biginelli condensation.
Journal ArticleDOI
Water Promoted One Pot Synthesis of Sesamol Derivatives as Potent Antioxidants: DFT, Molecular Docking, SAR and Single Crystal Studies
J. N. Lalpara,Sanjay D. Hadiyal,Bhvin B. Dhaduk,Maneesh K. Gupta,M. Solanki,Ashoke Sharon,G. G. Dubal +6 more
TL;DR: In this paper , a one pot water mediated synthesis of sesamol analogous using Betti base synthetic approach was proposed, where the reaction was optimized with various solvents and catalysts, but the product formed with a high yield in aqueous ethanol condition.
References
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Vancomycin-resistant enterococci.
TL;DR: This work reviews VRE, including their history, mechanisms of resistance, epidemiology, control measures, and treatment, and raises significant concerns about the emergence of vancomycin-resistant Staphylococcus aureus.
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A new method for determining the minimum inhibitory concentration of essential oils
C.M. Mann,Julie L. Markham +1 more
TL;DR: Use of 0·15% (w/v) agar as a stabilizer overcame the problem of adequate contact between the oil and the test bacteria and obviated the need to employ a chemical emulsifier.
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Four-membered ring-containing spirocycles: synthetic strategies and opportunities.
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The Pharmacology and Use of H1-Receptor-Antagonist Drugs
F. E. R. Simons,K. J. Simons +1 more
TL;DR: The second-generation H1-antagonist drugs are supplanting their predecessors in the treatment of allergic rhinoconjunctivitis and chronic urticaria and an even more favorable therapeutic index may be developed with the cloning of the gene encoding the H1 receptor and increased understanding of the precise structural requirements for H 1-receptor activity.
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Synthesis, antimicrobial, and anti-inflammatory activities of novel 2-(1-adamantyl)-5-substituted-1,3,4-oxadiazoles and 2-(1-adamantylamino)-5-substituted-1,3,4-thiadiazoles
Adnan A. Kadi,Nasser R. El-Brollosy,Omar A. Al-Deeb,El-Sayed E. Habib,Tarek M. Ibrahim,Ali A. El-Emam +5 more
TL;DR: The oxadiazole derivatives 4c, 4g, 4i and 4j produced good dose-dependent anti-inflammatory activity, particularly against the tested Gram-positive bacteria Bacillus subtilis and yeast-like pathogenic fungus Candida albicans.