Journal ArticleDOI
Design of a Highly Selective and Potent Class of Non‐planar Estrogen Receptor β Agonists.
Henrik Sundén,Jian-Nong Ma,Lars Kr. Hansen,Anna-Lena Gustavsson,Ethan S. Burstein,Roger Olsson,Roger Olsson,Roger Olsson +7 more
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This describes the syntheses of various dibenz ofurans and cycloheptanobenzofurans as estrogen receptor β agonists.Abstract:
This describes the syntheses of various dibenzofurans and cycloheptanobenzofurans as estrogen receptor β agonists.read more
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Versatility or Promiscuity: The Estrogen Receptors, Control of Ligand Selectivity and an Update on Subtype Selective Ligands
TL;DR: How nature controls ER specificity and how the subtle differences in receptor subtypes are exploited in pharmaceutical design to achieve binding specificity and subtype selectivity for desired biological response are discussed.
Journal ArticleDOI
Catalytic Enantioselective Pinacol and Meinwald Rearrangements for the Construction of Quaternary Stereocenters.
Hua Wu,Qian Wang,Jieping Zhu +2 more
TL;DR: Chiral N-triflyl phosphoramide-catalyzed enantioselective pinacol rearrangement of 1,2-tertiary diols and mechanistically related Meinwald rearrangements of tetrasubstituted epoxides for the synthe-sis of enantioenriched 2-alkynyl-2-arylcyclohexanones and 2,2 -diarylcyclo hexanones are reported.
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Journal ArticleDOI
Design of a highly selective and potent class of non-planar estrogen receptor β agonists.
Henrik Sundén,Jian-Nong Ma,Lars Kr. Hansen,Anna-Lena Gustavsson,Ethan S. Burstein,Roger Olsson,Roger Olsson,Roger Olsson +7 more
TL;DR: A new class of dihydrobenzofurans as potent and selective ERβ agonists and compound trans‐10‐SS appears to be the first molecule to take advantage of both conservative amino acid differences found in the α‐ and β‐faces of the binding cavities of ERα and ERβ.