Journal ArticleDOI
Detection of Hindered Rotation and Inversion by NMR Spectroscopy
TLDR
In this paper, the effects of substituents on the activation barriers of rotamers and invertomers were investigated, and the stability limits of isomers can also be determined.Abstract:
Rotations and inversions in organic molecules are readily recognizable from the temperature dependence of the NMR spectra. The study of the effects of substituents on the activation barriers of such processes permits the elucidation of reaction mechanisms, and the stability limits of isomers can also be determined. The knowledge of the stability limits is necessary for the specific synthesis of stable rotamers and invertomers.read more
Citations
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Journal ArticleDOI
Artificial Molecular Rotors
Journal ArticleDOI
Conformation and Biological Activity of Cyclic Peptides
TL;DR: In this paper, the authors proposed a model for peptide conformation analysis using NMR spectroscopic methods, including many recent advances, in relation to their ability to contribute to peptide conformational analysis.
Journal ArticleDOI
Peptidomimetics for Receptor Ligands—Discovery, Development, and Medical Perspectives
TL;DR: Peptidomimetics, compounds that act as substitutes for peptides in their interaction with receptors, have been synthesized and show higher metabolic stability, better bioavailability, and longer duration of action.
Journal ArticleDOI
Structure-Based Design of Inhibitors of Protein-Protein Interactions: Mimicking Peptide Binding Epitopes
TL;DR: A new classification of peptidomimetics (classes A–D) is introduced that enables a clear assignment of available approaches for the structure-based design of PPI inhibitors through stabilizing or mimicking turns, β-sheets, and helices.
Journal ArticleDOI
N-Methylation of Peptides : A New Perspective in Medicinal Chemistry
TL;DR: It is shown here for the first time that the simple approach of multiple N-methylation can drastically improve the metabolic stability and intestinal permeability of peptides, for example, resulting in 10% oral bioavailability for a tri-N-methylated Veber-Hirschmann peptide analog.
References
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Journal ArticleDOI
Specification of Molecular Chirality
TL;DR: In this article, the topological analysis of chiral molecular models has been extended to deal with organic-chemical conformations, and, on the other hand, with inorganic-chemical configurations to ligancy six.
Journal ArticleDOI
An Appraisal of Valence-bond Structures and Hybridization in Compounds of the First-row elements.
Journal ArticleDOI
Study of Moderately Rapid Chemical Exchange Reactions by Means of Nuclear Magnetic Double Resonance
Sture Forsén,Ragnar A. Hoffman +1 more
TL;DR: In this paper, a nuclear magnetic double resonance method for the determination of chemical exchange rates has been developed, which is applicable to systems in which a nuclear spin is reversibly transferred between two nonequivalent sites, A and B, and is obtained through the study of the decay to a new equilibrium value of Signal A upon the sudden saturation of Signal B.
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