Jayanta Chatterjee

TL;DR: It is shown here for the first time that the simple approach of multiple N-methylation can drastically improve the metabolic stability and intestinal permeability of peptides, for example, resulting in 10% oral bioavailability for a tri-N-methylated Veber-Hirschmann peptide analog.

TL;DR: Despite lower baseline risk, outcomes were similar in low- and middle-income compared with high-income countries and should also address the need for safe perioperative care.

TL;DR: The current knowledge of the versatility of N-methylation in modulating biological, structural, and pharmacokinetic properties of peptides is summarized.

TL;DR: It is possible to overcome the above mentioned bioavailability drawbacks of peptides providing both the biological activity and the receptor selectivity by multiple N-methylation of cyclic peptides.

TL;DR: The structural similarity of the second template structure with the orally bioavailable somatostatin analog cyclo(-Pro-Phe-NMe-D-Trp-N me-Lys-Thr-Nme-PHe-), and the striking resemblance with both β-turns of the orallyBioavailable peptide cyclosporine A, suggests that the introduction of bioactive sequences on the highly Caco-2 permeable templates may result in potent orally bio available drug