Journal ArticleDOI
Development of a short-term model of decalin inhalation nephrotoxicity in the male rat.
TLDR
The results indicate a sex and species specificity for the kidney toxicity in male rats, which leads to questions with regard to the appropriateness of using the male rat to assess the potential inhalation toxicity of volatile hydrocarbons.About:
This article is published in Food and Chemical Toxicology.The article was published on 1987-01-01. It has received 27 citations till now. The article focuses on the topics: Nephrotoxicity & Toxicity.read more
Citations
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Journal ArticleDOI
The comparative pathobiology of α2u-globulin nephropathy
TL;DR: This sustained increase in renal cell proliferation can promote initiated cells to form preneoplastic foci and renal neoplasia in male rats, and it is important to determine the relevance of these data for human risk assessment.
Journal Article
The Presence of α2u-Globulin Is Necessary for d-Limonene Promotion of Male Rat Kidney Tumors
TL;DR: It is concluded that dL promotes preneoplastic lesions and renal tumors only in the presence of the male rat-specific urinary protein, α2u-G, and extrapolation of dL carcinogenicity data from rat studies to other species, including humans, is probably not warranted.
Journal ArticleDOI
α2u-globulin is the only member of the lipocalin protein superfamily that binds to hyaline droplet inducing agents
TL;DR: Evaluated in vitro binding experiments provide direct evidence that the presence of the alpha 2u-globulin superfamily proteins does not predispose humans to develop hyaline droplet nephropathy and renal cancer from this class of chemicals.
Journal ArticleDOI
A Review of Unique Male Rat Hydrocarbon Nephropathy
TL;DR: The male rat hydrocarbon nephropathy should not be predictive of a normal human renal response, as only male rats develop kidney alterations upon exposure to these chemicals.
Journal ArticleDOI
Comparison of short-term renal effects due to oral administration of decalin or d-limonene in young adult male Fischer-344 rats
TL;DR: A uniformity of primary and secondary renal responses to the two chemicals is demonstrated, strongly suggesting that the morphogenesis of d-limonene-associated nephrotoxicity in the adult male rat is consistent with that of decalin.
References
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Journal ArticleDOI
Range-Finding Toxicity Data: List VII
TL;DR: In this article, acute toxicity and irritation data on about 200 compounds are presented, accumulated in a continuing program for screening potential commercial products, and the authors present a detailed discussion of the results.
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Petroleum hydrocarbon toxicity studies. VI. Animal and human responses to vapors of "60 Solvent".
TL;DR: Based upon 15-min inhalation periods by humans and the animal findings, the concentration judged acceptable for 8 hr/day, 5 days/week of inhalation was 0.44 mg/liter (90 ppm), which was well tolerated by human volunteers in sensory threshold studies.
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Petroleum hydrocarbon toxicity studies: III. Animal and human response to vapors of Stoddard Solvent
TL;DR: The suggested hygienic standard for inhalation of Stoddard solvent for man is 1.2 mg/liter (200 ppm) based upon the results of inhalation studies with rats and dogs and sensory response of human subjects.