Development of cold-adapted recombinant live, attenuated influenza A vaccines in the U.S.A. and U.S.S.R.
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TLDR
The ability to recombine influenza viruses by mixed infections during which the segmented RNA genome can reassort raised the prospect that once a suitable attenuated vaccine strain of influenza A was prepared, this property could be transferred to a new strain with contemporary HA and NA antigens.About:
This article is published in Antiviral Research.The article was published on 1982-02-01 and is currently open access. It has received 79 citations till now. The article focuses on the topics: Original antigenic sin & Attenuated vaccine.read more
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Prevention and control of influenza : recommendations of the Advisory Committee on Immunization Practices (ACIP)
TL;DR: This report updates the 2000 recommendations by the Advisory Committee on Immunization Practices on the use of influenza vaccine and antiviral agents with new or updated information regarding the cost-effectiveness of influenza vaccination and the 2001-2002 trivalent vaccine virus strains.
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The evolving history of influenza viruses and influenza vaccines
TL;DR: The history of influenza vaccine and the associated technology shows how the vaccine has evolved to match the evolution of influenza viruses.
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Identification of sequence changes in the cold-adapted, live attenuated influenza vaccine strain, A/Ann Arbor/6/60 (H2N2).
TL;DR: In this article, RNA segments encoding the PB2, P131, PA, NP, M1, M2, NS1, and NS2 proteins of the influenza A/Ann Arbor/6/60 (H2N2) wild-type (wt) virus and its cold-adapted (ca) derivative that has been used for preparing investigational live attenuated vaccines were obtained.
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Development and characterization of cold-adapted viruses for use as live virus vaccines
Hunein F. Maassab,Dan C. DeBorde +1 more
TL;DR: Overall, the best method of cold adaptation to develop a live virus vaccine line appeared to be a stepwise lowering of the growth temperature allowing time for multiple lesions to occur and/or be selected.
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Immunogenicity and protection efficacy of replication-deficient influenza A viruses with altered NS1 genes.
Boris Ferko,Jana Stasakova,Julia Romanova,Christian Kittel,Sabine Sereinig,Hermann Katinger,Andrej Egorov +6 more
TL;DR: Findings indicate that a targeted modification of the RNA-binding domain of the NS1 protein is a valuable technique to generate replication-deficient, but immunogenic influenza virus vaccines.
References
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Interpandemic Influenza in the Houston Area, 1974–76
Glezen Wp,Couch Rb +1 more
TL;DR: Observations support the concept of rapid dissemination of influenza among schoolchildren and suggest that control of epidemic influenza might be facilitated by prophylaxis for that age group and other accessible, healthy populations.
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Impact of epidemic type a influenza in a defined adult population
TL;DR: The authors study the occurrence of excess morbidity and mortality among subsets of the adult population of a large prepaid group practice during two epidemics of type A influenza to provide a basis for increasing the precision of clinical and public decision-making regarding the prevention of serious consequences of epidemic influenza.
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Assessment of inactivated influenza-A vaccine after three outbreaks of influenza A at Christ's Hospital.
TL;DR: It is suggested that annual revaccination with inactivated influenza-A vaccine confers no long-term advantage.
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Adaptation and Growth Characteristics of Influenza Virus at 25° C
TL;DR: This work has shown that a relationship has been observed between virulence and the ability to grow at lower temperatures, and this has been used in the selection of attenuated variants.
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Isolation and preliminary characterization of temperature-sensitive mutants of vaccinia virus.
TL;DR: Methods have been developed for rapid isolation and genetic analysis of vaccinia virus mutants and four phenotypes appear: normal, a phenotype associated with DNA-negative mutants characterized by prolonged synthesis of early proteins and the absence of lateprotein synthesis, weak or slow late protein synthesis, and abortiveLate protein synthesis.