Differential effects of d-amphetamine in classical discrimination conditioning of rabbits
William Peel,Arthur L. Yehle +1 more
TLDR
D-Amphetamine was administered to rabbits performing a “difficult” and an “easy” classical discrimination task and the results provide support for the “cue-monitoring” interpretation of amphetamine facilitation and the observed divergence of response systems in the rabbit.Abstract:
D-Amphetamine was administered to rabbits performing a “difficult” and an “easy” classical discrimination task. The drug had no significant effect on overall nictitating membrane responding whereas it debilitated heart rate responding. Heart rate discrimination was debilitated for both tasks; however, amphetamine facilitated nictitating membrane discrimination for the “difficult” task while having no effect on the “easy” task. The results are discussed in terms of support for the “cue-monitoring” interpretation of amphetamine facilitation and the observed divergence of response systems in the rabbit.read more
Citations
More filters
Journal ArticleDOI
A pharmacological analysis of processes underlying differential responding: a review and further experiments with scopolamine, amphetamine, lysergic acid diethylamide (LSD-25), chlordiazepoxide, physostigmine, and chlorpromazine.
TL;DR: The fact that the LSD-25 disinhibition depends on response-reinforcement relations in no go trials, and not on task difficulty per se, suggests that the mechanisms underlying response withholding with an extinction and with a passive avoidance contingency, respectively, are at least in part separated from each other, even when stimulus factors appear to make comparable contributions to the overall variance.
Journal ArticleDOI
Use of classical conditioning procedures in behavioral pharmacology
TL;DR: The current paper details the behavioral techniques which have been developed to study the effects of drugs, in particular the opioids, on classical conditioning.
Journal ArticleDOI
Effect of LSD on acquisition, maintenance, extinction and differentiation of conditioned responses
TL;DR: The results of Experiments 1 and 2 were interpreted as indicating that LSD produces an asymmetrical state-dependent learning.
Journal ArticleDOI
Delta 9-tetrahydrocannabinol: elevation of absolute visual thresholds of rabbits.
TL;DR: Both of two dosage levels of THC, similar to an amount ingested by a human from a single cigarette, significantly elevated the absolute visual threshold of all animals, however, normal baseline thresholds returned with 24 hours.
Journal ArticleDOI
Experimental effects of amphetamine: supplementary report.
TL;DR: As a supplement to a previous review, generalizations related to the experimental effects of amphetamine on food-motivated operant behavior, bodily activity and avoidance conditioning are evaluated in terms of recent evidence.
References
More filters
Journal ArticleDOI
The Pharmacological Basis of Therapeutics
Journal ArticleDOI
A method for transducing nictitating membrane and breathing rate responses in the rabbit.
Journal ArticleDOI
Restoration of tracking proficiency as a function of amount and delay of analeptic medication.
Journal ArticleDOI